Chunhong Liang, Jin Lv, Qin Zhang, Guohui Xie
Department of Spine Surgery, Yuncheng Central Hospital of Shanxi Province, Yuncheng, Shanxi, China.
Department of Traditional Chinese Medicine, Yuncheng Central Hospital of Shanxi Province, Yuncheng, Shanxi, China.
Pak J Pharm Sci. 2018 May;31(3(Special)):1131-1135.
In recent years, the concept of treatment after surgery in the department of orthopedics has changed from hemostasis to anticoagulant. This article analyses the safety and effectiveness of anticoagulants for prophylactic anticoagulants after spinal fractures. By analyzing the incidence of bleeding and VTE in 2 weeks after operation, there was no significant difference between the 2 groups (P>0.05), but the incidence of VTE in rivaroxaban group was significantly lower than that in control group. In conclusion, the rivaroxaban oral anticoagulants are stable, safe and easy to use. It significantly reduced the incidence of VTE after spinal fracture and nerve injury, and did not increase the risk of bleeding. It is an ideal type of prophylactic anticoagulant after the operation of spinal fracture, which is worthy of further clinical study.
近年来，骨科术后治疗理念已从止血转变为抗凝。本文分析了抗凝剂用于脊柱骨折后预防性抗凝的安全性和有效性。通过分析术后2周出血和VTE的发生率，两组之间无显著差异（P>0.05），但利伐沙班组的VTE发生率显著低于对照组。综上所述，利伐沙班口服抗凝剂稳定、安全且使用方便。它显著降低了脊柱骨折和神经损伤后VTE的发生率，且未增加出血风险。它是脊柱骨折术后预防性抗凝的理想类型，值得进一步临床研究。
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