转基因小鼠晶状体发育的扰动。
Perturbations of lens development in the transgenic mouse.
作者信息
Westphal H
机构信息
Section on Mammalian Gene Regulation, National Institute of Child Health and Human Development, Bethesda, MD 20892.
出版信息
Cell Differ Dev. 1988 Nov;25 Suppl:33-7. doi: 10.1016/0922-3371(88)90097-4.
Interference with specific features of cell growth and differentiation in vivo offers rare insights into the complex mechanism of cell proliferation in the developing organism. We have inserted in the germ line of mice transgenes which direct dominant changes in cell development and proliferation to the lens, a tissue exquisitely suited for in vivo analysis. Lens-specific expression of SV40 T antigens results in malignant lens tumors or phakomas, that of a murine c-mos protooncogene in a characteristic defect of lens fiber differentiation.
干扰体内细胞生长和分化的特定特征，为深入了解发育中生物体细胞增殖的复杂机制提供了难得的见解。我们已将指导细胞发育和增殖向晶状体发生显性变化的转基因插入小鼠种系，晶状体是一种非常适合进行体内分析的组织。SV40 T抗原的晶状体特异性表达会导致恶性晶状体肿瘤或晶状体瘤，而鼠源c-mos原癌基因的晶状体特异性表达则会导致晶状体纤维分化出现特征性缺陷。
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