Berti Francesco, Arif Zeeshan, Constantinescu Cris, Gran Bruno
Division of Clinical Neuroscience, University of Nottingham School of Medicine, Nottingham, UK.
Department of Neurology, Nottingham University Hospitals NHS Trust, Nottingham, UK.
Case Rep Neurol Med. 2018 Mar 21;2018:2768493. doi: 10.1155/2018/2768493. eCollection 2018.
Hypothermia is a rare and poorly understood complication of Multiple Sclerosis (MS). We report on a 66-year-old patient currently with Secondary Progressive MS (SP-MS) who developed unexplained hypothermia associated with multiple hospitalisations and we review the literature on this topic. In our case, magnetic resonance imaging (MRI) of the brain failed to highlight hypothalamic disease, but spinal MRI identified a number of spinal cord lesions. Given the incidence and clinical significance of spinal involvement in MS and the hypothermic disturbances observed in high Spinal Cord Injury (SCI), we hypothesise that upper spinal cord pathology, along with hypothalamic and brainstem dysfunctions, can contribute to hypothermia.
体温过低是多发性硬化症（MS）一种罕见且了解甚少的并发症。我们报告了一名66岁患有继发进展型多发性硬化症（SP-MS）的患者，该患者出现了与多次住院相关的不明原因体温过低情况，并对该主题的文献进行了综述。在我们的病例中，脑部磁共振成像（MRI）未能显示下丘脑疾病，但脊髓MRI发现了一些脊髓病变。鉴于脊髓受累在MS中的发生率及临床意义，以及在高位脊髓损伤（SCI）中观察到的体温过低紊乱情况，我们推测脊髓上段病变，连同下丘脑和脑干功能障碍，可能导致体温过低。
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