多囊卵巢综合征患者的垂体体积会发生变化吗？
Does the Pituitary Gland Volume Change in Polycystic Ovary Syndrome?
作者信息
Bozkurt Koseoglu Sezen, Dinc Elibol Funda
机构信息
Department of Gynecology and Obstetrics, Mugla Sitki Kocman Training and Research Hospital, Mugla, Turkey.
Department of Radiology, Mugla Sitki Kocman Training and Research Hospital, Mugla, Turkey.
出版信息
Gynecol Obstet Invest. 2018;83(5):515-519. doi: 10.1159/000489495. Epub 2018 May 15.
AIMS
Polycystic ovary syndrome (PCOS) is the commonest cause of menstrual irregularity and hirsutism during reproductive age. We hypothesized in the alterations in the pituitary gland in PCOS.
METHODS
We measured the volume of the pituitary gland in 39 PCOS patients and 42 age-matched healthy controls using 0.35 mm thick T1-weighted sagittal cranial images. Serum levels of estradiol (E2), luteinizing hormone (LH), and follicle-stimulating hormone (FSH) were measured on days 3-5 of the menstrual cycle of the participants.
RESULTS
There was a significant difference in terms of LH, FSH, and LH/FSH ratio (p < 0.05) between groups. Mean pituitary gland volume (PGV) was 4.1 ± 1.36 mm3 for the study group and 3.4 ± 0.77 mm3 for the control group. PGV was statistically significantly higher in PCOS group than the control group (p < 0.05). There was no correlation between hormone levels and PGVs in groups.
CONCLUSION
Enlarged pituitary volume in PCOS may be due to excessive LH release.
目的
多囊卵巢综合征（PCOS）是育龄期月经不调和多毛症最常见的原因。我们推测PCOS患者垂体存在改变。
方法
我们使用0.35毫米厚的T1加权矢状位头颅图像测量了39例PCOS患者和42例年龄匹配的健康对照者的垂体体积。在参与者月经周期的第3 - 5天测量血清雌二醇（E2）、黄体生成素（LH）和卵泡刺激素（FSH）水平。
结果
两组之间在LH、FSH和LH/FSH比值方面存在显著差异（p < 0.05）。研究组的平均垂体体积（PGV）为4.1 ± 1.36立方毫米，对照组为3.4 ± 0.77立方毫米。PCOS组的PGV在统计学上显著高于对照组（p < 0.05）。两组中激素水平与PGV之间均无相关性。
结论
PCOS患者垂体体积增大可能是由于LH过度释放所致。
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