Wang Dan, Zhang Zhang, Yang Fan, Zhang Le, Yang Zhenwen, Ren Wen, Yu Tielian, Li Dong
Department of Radiology, Tianjin Medical University General Hospital, Tianjin 300052, China.
Department of Cardiovascular Disease, Tianjin Medical University General Hospital, Tianjin 300052, China.
Zhongguo Fei Ai Za Zhi. 2018 May 20;21(5):397-402. doi: 10.3779/j.issn.1009-3419.2018.05.07.
To study the characteristics of ventricular function in Pulmonary Hypertension (PH) Patients with different shape of Interventricular Septum (IVS) by cardiac magnetic resonance (CMR).
36 PH patients diagnosed by right heart catheterization accepted CMR. According to the morphology of IVS, the patients were divided into two groups: the non-deformation group (10 patients) and the deformation group (26 patients). The ventricular function parameters were as follows: RV and LV end-diastolic volume index (EDVI), end-systolic volume index (ESVI), stroke volume index (SVI), cardiac index (CI), ejection fraction (EF), and myocardial mass index (MMI).
ANOVA analysis showed that the differences of RVEDVI, RVESVI, RVSVI, RVCI, RVEF, RVMMI, LVEDVI, LVESVI, LVSVI and LVCI were significant among the three groups. Compared with control group, RVSVI (P=0.017), RVEF (P<0.001), LVEDVI (P=0.048) and LVSVI (P=0.015) decreased in IVS non-deformation group. Compared with IVS non-deformation group, RVEDVI (P<0.001), RVESVI (P<0.001), RVCI (P=0.002) and RVMMI (P=0.017) were increased in IVS deformation group; while RVEF (P=0.001), LVEDVI (P=0.003), LVSVI (P<0.001) and LVCI (P=0.029) were decreased. Compared with the control group, RVEDVI (P<0.001), RVESVI (P<0.001), RVCI (P=0.004) and RVMMI (P=0.003) were increased in the IVS deformation group, while RVEF (P<0.001), LVEDVI (P<0.001), LVESVI (P<0.001), LVSVI (P<0.001), LVCI (P<0.001) were decreased.
Ventricular function is different in PH Patients with different IVS shape. The IVS shape can represent the changes of ventricular function in PH patients.
通过心脏磁共振成像（CMR）研究不同室间隔（IVS）形态的肺动脉高压（PH）患者的心室功能特征。
36例经右心导管检查确诊的PH患者接受CMR检查。根据IVS形态，将患者分为两组：无变形组（10例）和变形组（26例）。心室功能参数如下：右心室和左心室舒张末期容积指数（EDVI）、收缩末期容积指数（ESVI）、每搏输出量指数（SVI）、心指数（CI）、射血分数（EF）和心肌质量指数（MMI）。
方差分析显示，三组之间右心室舒张末期容积指数（RVEDVI）、右心室收缩末期容积指数（RVESVI）、右心室每搏输出量指数（RVSVI）、右心室心指数（RVCI）、右心室射血分数（RVEF）、右心室心肌质量指数（RVMMI）、左心室舒张末期容积指数（LVEDVI）、左心室收缩末期容积指数（LVESVI）、左心室每搏输出量指数（LVSVI）和左心室心指数（LVCI）存在显著差异。与对照组相比，IVS无变形组的RVSVI（P = 0.017）、RVEF（P < 0.001）、LVEDVI（P = 0.048）和LVSVI（P = 0.015）降低。与IVS无变形组相比，IVS变形组的RVEDVI（P < 0.001）、RVESVI（P < 0.001）、RVCI（P = 0.002）和RVMMI（P = 0.017）升高；而RVEF（P = 0.001）、LVEDVI（P = 0.003）、LVSVI（P < 0.001）和LVCI（P = 0.029）降低。与对照组相比，IVS变形组的RVEDVI（P < 0.001）、RVESVI（P < 0.001）、RVCI（P = 0.004）和RVMMI（P = 0.003）升高，而RVEF（P < 0.001）、LVEDVI（P < 0.001）、LVESVI（P < 0.001）、LVSVI（P < 0.001）、LVCI（P < 0.001）降低。
不同IVS形态的PH患者心室功能不同。IVS形态可反映PH患者心室功能的变化。
