草酸纳洛昔醇呈现出一种氢键层状结构。
Naloxegol hydrogen oxalate displaying a hydrogen-bonded layer structure.
作者信息
Gelbrich Thomas, Langes Christoph, Stefinovic Marijan, Griesser Ulrich J
机构信息
University of Innsbruck, Institute of Pharmacy, Innrain 52, 6020 Innsbruck, Austria.
Sandoz GmbH, Biochemiestrasse 10, 6250 Kundl, Austria.
出版信息
Acta Crystallogr E Crystallogr Commun. 2018 Mar 9;74(Pt 4):474-477. doi: 10.1107/S2056989018003675. eCollection 2018 Apr 1.
In the salt (5α,6α)-6-[(2,5,8,11,14,17,20-hepta-oxadocosan-22-yl)-oxy]-3,14-dihy-droxy-17-(prop-2-en-1-yl)-4,5-ep-oxy-morphinan-17-ium hydrogen oxalate, CHNO·CHO the polyether unit of the naloxegol cation adopts the shape of a squashed open letter 'O'. In the crystal, the hydrogen oxalate anions are linked into a chain by O-H⋯O hydrogen bonds. Each naloxegol unit is hydrogen bonded to three hydrogen oxalate ions two O-H⋯O and one N-H⋯O inter-actions. The resulting hydrogen-bonded two-dimensional layer structure is 3,5-connected and has the topology.
在盐（5α，6α）-6-[(2,5,8,11,14,17,20-七氧杂二十二烷-22-基）-氧基]-3,14-二羟基-17-（丙烯-1-基）-4,5-环氧吗啡喃-17-鎓草酸氢盐，CHNO·CHO中，纳洛西醇阳离子的聚醚单元呈压扁的开口字母“O”形状。在晶体中，草酸氢根阴离子通过O-H⋯O氢键连接成链。每个纳洛西醇单元通过两个O-H⋯O和一个N-H⋯O相互作用与三个草酸氢根离子形成氢键。由此产生的氢键二维层状结构是3,5连接的且具有该拓扑结构。
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