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[残胃癌的预后及影响因素]

[Prognostic and influential factors of gastric stump cancer].

作者信息

Li Ziyu, Wang Yinkui, Ji Jiafu

机构信息

Department of Gastrointestinal Cancer Center, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education), Peking University Cancer Hospital and Institute, Beijing 100142, China.

出版信息

Zhonghua Wei Chang Wai Ke Za Zhi. 2018 May 25;21(5):491-497.

Abstract

Gastric stump cancer was first defined as cancer occurring in the remnant stomach 5 years or later following distal subtotal gastrectomy of a benign stomach tumor. This definition was expanded to include malignant gastric cancer recurrence following distal gastrectomy and heterochronous gastric adenocarcinoma. Evidence regarding whether patients with gastric stump cancer had the same prognosis as those with primary gastric cancer has been inconsistent. Nonetheless, considering the notable differences regarding risk factors, treatment strategies, and lymph node metastasis status, gastric stump cancer should be differentiated from primary stomach cancer. Overall, the prognosis of gastric stump cancer is influenced by clinicopathological characteristics such as primary tumor features, location of gastric stump cancer, histological type, invasion depth, lymph node metastasis, and distant metastasis, as well as treatment factors such as treatment strategy, dissection range, and lymph node resection range. In previous studies on gastric stump cancer, the sample size was limited, and future studies with larger sample size are needed to further validate the prognostic factors of gastric stump cancer.

摘要

胃残端癌最初被定义为良性胃肿瘤远端次全胃切除术后5年或更晚发生于残胃的癌症。这一定义已扩大到包括远端胃切除术后恶性胃癌复发和异时性胃腺癌。关于胃残端癌患者的预后是否与原发性胃癌患者相同的证据并不一致。尽管如此,考虑到在危险因素、治疗策略和淋巴结转移状态方面的显著差异,胃残端癌应与原发性胃癌相区分。总体而言,胃残端癌的预后受临床病理特征影响,如原发肿瘤特征、胃残端癌位置、组织学类型、浸润深度、淋巴结转移和远处转移,以及治疗因素,如治疗策略、切除范围和淋巴结切除范围。在先前关于胃残端癌的研究中,样本量有限,未来需要更大样本量的研究来进一步验证胃残端癌的预后因素。

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