血清胱抑素 C 和高敏 C 反应蛋白与系统性红斑狼疮患者血管内皮细胞损伤的相关性。

Correlations of serum cystatin C and hs-CRP with vascular endothelial cell injury in patients with systemic lupus erythematosus.

机构信息

Department of Dermatology, Yantai Yuhuangding Hospital, Yantai, China.

Department of Dermatology, Yantai Yuhuangding Hospital, Yantai, China -

出版信息

Panminerva Med. 2018 Dec;60(4):151-155. doi: 10.23736/S0031-0808.18.03466-3. Epub 2018 May 22.

DOI:10.23736/S0031-0808.18.03466-3

PMID:29792017

Abstract

BACKGROUND

To investigate the correlations of serum cystatin C and high-sensitivity C-reactive protein (hs-CRP) with vascular endothelial cell injury in patients with active systemic lupus erythematosus (SLE).

METHODS

A total of 80 patients with SLE treated in our hospital from January 2016 to September 2017 were selected and randomly divided into stable-stage group (N.=40) and active-stage group (N.=40) using a random number table. The expressions of cystatin C and hs-CRP in stable and active stages were compared, and the inner diameters of brachial artery and levels of vascular endothelial growth factors in stable and active stages were also compared. The correlations of expressions of cystatin C and hs-CRP in active stage with the inner diameter of brachial artery and vascular endothelial growth factor were analyzed. At the same time, the correlation between vascular endothelial growth factor and inner diameter of brachial artery in active stage was analyzed.

RESULTS

The level of cystatin C in active stage was higher than that in stable stage (P<0.05), and the expression level of hs-CRP in active stage was also higher than that in stable stage (P<0.05). The inner diameter of brachial artery in active stage was smaller than that in stable stage (P<0.05), but the level of vascular endothelial growth factor (VEGF) was higher than that in stable stage (P<0.05). The expressions of cystatin C and hs-CRP were negatively correlated with the inner diameter of brachial artery in active stage (P<0.05). The expressions of cystatin C and hs-CRP were positively correlated with VEGF in active stage (P<0.05). Moreover, there was a negative correlation between VEGF and inner diameter of brachial artery in active stage (P<0.05).

CONCLUSIONS

Levels of cystatin C and hs-CRP are significantly increased in patients with active SLE, and the increase degrees are negatively correlated with the inner diameter of brachial artery under ultrasound, but positively correlated with the level of VEGF in vivo.

摘要

背景

探讨血清胱抑素 C 和高敏 C 反应蛋白（hs-CRP）与活动期系统性红斑狼疮（SLE）患者血管内皮细胞损伤的相关性。

方法

选取 2016 年 1 月至 2017 年 9 月在我院治疗的 80 例 SLE 患者，采用随机数字表法分为稳定期组（n=40）和活动期组（n=40）。比较稳定期和活动期患者的胱抑素 C 和 hs-CRP 表达，比较稳定期和活动期患者肱动脉内径及血管内皮生长因子水平，分析活动期胱抑素 C 和 hs-CRP 表达与肱动脉内径及血管内皮生长因子的相关性，同时分析活动期血管内皮生长因子与肱动脉内径的相关性。

结果

活动期胱抑素 C 水平高于稳定期（P<0.05），hs-CRP 表达水平也高于稳定期（P<0.05）。活动期肱动脉内径小于稳定期（P<0.05），但血管内皮生长因子（VEGF）水平高于稳定期（P<0.05）。活动期胱抑素 C 和 hs-CRP 表达与肱动脉内径呈负相关（P<0.05）。活动期胱抑素 C 和 hs-CRP 表达与 VEGF 呈正相关（P<0.05）。此外，活动期 VEGF 与肱动脉内径呈负相关（P<0.05）。