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下一代贴片泵的功能:更高的精度、即时阻塞检测和双激素疗法。

Capabilities of Next-Generation Patch Pump: Improved Precision, Instant Occlusion Detection, and Dual-Hormone Therapy.

作者信息

Payne Forrest W, Ledden Bradley, Lamps Greg

机构信息

1 SFC Fluidics, Inc, Fayetteville, AR, USA.

出版信息

J Diabetes Sci Technol. 2019 Jan;13(1):49-54. doi: 10.1177/1932296818776028. Epub 2018 May 24.

Abstract

Insulin pumps allow patients to attain better blood glucose control with more lifestyle flexibility. Their size and cost, however, limit their usefulness. Current CSII pumps are bulky, intrusive, and expensive. SFC Fluidics is addressing these problems by developing a new type of wearable patch pump based on the patented electro-chemiosmotic (ECO) microfluidic pumping technology. This nonmechanical pumping technology allows accurate and precise delivery of very small amounts of insulin and/or other drugs, including concentrated insulin. The pump engine is small and can be made inexpensively from injection molded parts, allowing its use in a disposable or semidisposable pod format. In addition, a single ECO pump engine can be used to deliver two drugs through independent pathways. Other features of SFC Fluidics' pod include latching safety valves that prevent accidental overdosing of insulin due to pressure changes and an instantaneous occlusion sensor that can immediately detect delivery failure at the first missed dose. These features allow for the development of a series of patch pumps that will offer users the benefit of CSII therapy in a more discreet and reliable patch pump form.

摘要

胰岛素泵使患者能够在生活方式上更具灵活性的同时更好地控制血糖。然而,其尺寸和成本限制了它们的实用性。目前的持续皮下胰岛素输注(CSII)泵体积庞大、具有侵入性且价格昂贵。SFC流体技术公司正在通过基于专利的电化学渗透(ECO)微流体泵送技术开发一种新型可穿戴贴片泵来解决这些问题。这种非机械泵送技术能够准确精确地输送极少量的胰岛素和/或其他药物,包括浓缩胰岛素。泵引擎体积小,并且可以用注塑部件廉价制造,使其能够以一次性或半一次性药盒的形式使用。此外,单个ECO泵引擎可用于通过独立路径输送两种药物。SFC流体技术公司药盒的其他特点包括防止因压力变化导致胰岛素意外过量的锁定安全阀,以及能够在首次漏服剂量时立即检测输送失败的即时阻塞传感器。这些特点有助于开发一系列贴片泵,以更隐蔽、可靠的贴片泵形式为用户提供CSII治疗的益处。

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