恩前列素对健康人基础胃酸和胃蛋白酶分泌、进餐刺激的胃酸和胃蛋白酶分泌、血清胃泌素及胃排空的影响。

Effect of enprostil on basal and meal-stimulated gastric acid and pepsin secretion, serum gastrin and gastric emptying in healthy persons.

作者信息

Berstad K, Massey H, Berstad A

机构信息

Medical Department, Lovisenberg Hospital, Oslo, Norway.

出版信息

Aliment Pharmacol Ther. 1988 Feb;2(1):65-72. doi: 10.1111/j.1365-2036.1988.tb00673.x.

DOI:10.1111/j.1365-2036.1988.tb00673.x

PMID:2979235

Abstract

Ten healthy volunteers took part in a double-blind, randomized, cross-over study of the effect of single doses of enprostil (70 micrograms) and placebo on basal and meal-stimulated gastric acid, pepsin secretion and serum gastrin. Meal-stimulation was induced by modified sham feeding combined with repeated gastric instillation and withdrawal of meat soup. When studied between 1 and 2.5 hours after oral administration of the drug, enprostil decreased basal acid output by 92% (P less than 0.001) and stimulated acid output by 70% (P less than 0.001). Basal and stimulated volumes of gastric juice were decreased by 50% (P less than 0.02) and 35% (P less than 0.002), respectively. Enprostil decreased stimulated pepsin output by 34% (P less than 0.05), but had no effect on the concentration of pepsin. Neither basal nor stimulated serum gastrin concentrations were affected by enprostil. Percent recovery of the meal was measured by an unabsorbable marker, polyethylene glycol, instilled into the stomach mixed with the soup. Polyethylene glycol recovery decreased from 89% with placebo to 67% with enprostil (P less than 0.01), indicating an enhanced gastric emptying rate with enprostil.

摘要

十名健康志愿者参与了一项双盲、随机、交叉研究，该研究旨在探讨单剂量恩前列素（70微克）和安慰剂对基础胃酸分泌、进餐刺激胃酸分泌、胃蛋白酶分泌及血清胃泌素的影响。通过改良假饲联合重复胃内灌注和抽取肉汤来诱导进餐刺激。在口服药物后1至2.5小时进行研究时，恩前列素使基础胃酸分泌量降低了92%（P<0.001），并使刺激胃酸分泌量增加了70%（P<0.001）。基础胃液量和刺激胃液量分别降低了50%（P<0.02）和35%（P<0.002）。恩前列素使刺激胃蛋白酶分泌量降低了34%（P<0.05），但对胃蛋白酶浓度没有影响。恩前列素对基础血清胃泌素浓度和刺激血清胃泌素浓度均无影响。通过将不可吸收标记物聚乙二醇与肉汤混合后注入胃内来测量进餐的回收率。聚乙二醇回收率从安慰剂组的89%降至恩前列素组的67%（P<0.01），表明恩前列素可提高胃排空率。