Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia; Department of Radiation Oncology, Chris O'Brien Lifehouse, Camperdown, Australia.
Central Clinical School, Faculty of Medicine and Health, The University of Sydney, Sydney, Australia.
Clin Oncol (R Coll Radiol). 2018 Sep;30(9):589-592. doi: 10.1016/j.clon.2018.05.002. Epub 2018 May 24.
To determine the outcome after radiation therapy for desmoid fibromatosis.
A retrospective review of 50 patients treated between 1988 and 2016 in a specialised bone and soft tissue tumour clinic.
The median age at the time of radiation therapy was 36.8 years (range 15.1-69.0) and the median follow-up time was 51 months. Forty-three patients underwent radiation therapy as the definitive treatment with a median dose of 56 Gy (range 30-58.8 Gy). The median dose for the seven patients treated with postoperative radiation therapy was 50.4 Gy (range 48-56 Gy). Eleven patients (22%) developed progressive disease after radiation therapy at a median time of 41 months (range 12-113 months). The recurrences were within the radiation therapy field in four patients and outside the field in seven patients. One patient developed a radiation-induced malignancy 20 years after treatment.
Radiation therapy is an alternative treatment in the management of desmoid fibromatosis. It should be considered in patients for whom surgical resection is not feasible, or as adjuvant therapy after surgery with involved margins where any further recurrences would cause significant morbidity.
确定纤维瘤病放疗后的结果。
对 1988 年至 2016 年在专门的骨与软组织肿瘤诊所治疗的 50 例患者进行回顾性分析。
放疗时的中位年龄为 36.8 岁（范围 15.1-69.0），中位随访时间为 51 个月。43 例患者接受放疗作为确定性治疗，中位剂量为 56 Gy（范围 30-58.8 Gy）。7 例术后放疗患者的中位剂量为 50.4 Gy（范围 48-56 Gy）。11 例（22%）患者在放疗后中位时间 41 个月（范围 12-113 个月）出现疾病进展。4 例患者在放疗野内复发，7 例患者在放疗野外复发。1 例患者在治疗 20 年后发生放射性恶性肿瘤。
放疗是纤维瘤病治疗的一种替代方法。对于手术切除不可行的患者，或对于边缘受累的手术切除后需要进一步复发会导致明显发病率的患者，应考虑作为辅助治疗。
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