睡眠期间的长期部分性梗阻是一种非快速眼动（NREM）现象。
Prolonged partial obstruction during sleep is a NREM phenomenon.
作者信息
Himanen Sari-Leena, Martikkala Lauri, Sulkamo Saramia, Rutanen Antti, Huupponen Eero, Tenhunen Mirja, Saunamäki Tiia
机构信息
Department of Clinical Neurophysiology, Medical Imaging Centre and Hospital Pharmacy, Pirkanmaa Hospital District, Tampere, Finland; Faculty of Medicine and Life Sciences, University of Tampere, Tampere, Finland.
Department of Clinical Neurophysiology, Medical Imaging Centre and Hospital Pharmacy, Pirkanmaa Hospital District, Tampere, Finland.
出版信息
Respir Physiol Neurobiol. 2018 Sep;255:43-49. doi: 10.1016/j.resp.2018.05.009. Epub 2018 May 24.
OBJECTIVE
Prolonged partial obstruction (PPO) is a common finding in sleep studies. Although not verified, it seems to emerge in deep sleep. We study the effect of PPO on sleep architecture or sleep electroencephalography (EEG) frequency.
METHODS
Fifteen OSA patients, 15 PPO + OSA patients and 15 healthy subjects underwent a polysomnography. PPO was detected from Emfit mattress signal. Visual sleep parameters and median NREM sleep frequency of the EEG channels were evaluated.
RESULTS
The amount of deep sleep (N3) did not differ between the PPO + OSA and control groups (medians 11.8% and 13.8%). PPO + OSA-patients' N3 consisted mostly of PPO. PPO + OSA patients had lighter sleep than healthy controls in three brain areas (Fp2-A1, C4-A1, O1-A2, p-values < 0.05).
CONCLUSION
PPO evolved in NREM sleep and especially in N3 indicating that upper airway obstruction does not always ameliorate in deep sleep but changes the type. Even if PPO + OSA-patients had N3, their NREM sleep was lighter in three EEG locations. This might reflect impaired recovery function of sleep.
目的
长期部分性梗阻（PPO）是睡眠研究中的常见发现。尽管未经证实，但它似乎出现在深度睡眠中。我们研究PPO对睡眠结构或睡眠脑电图（EEG）频率的影响。
方法
15名阻塞性睡眠呼吸暂停（OSA）患者、15名PPO + OSA患者和15名健康受试者接受了多导睡眠图检查。从Emfit床垫信号中检测到PPO。评估了视觉睡眠参数和EEG通道的非快速眼动（NREM）睡眠频率中位数。
结果
PPO + OSA组和对照组之间的深度睡眠（N3）量没有差异（中位数分别为11.8%和13.8%）。PPO + OSA患者的N3主要由PPO组成。在三个脑区（Fp2 - A1、C4 - A1、O1 - A2，p值<0.05），PPO + OSA患者的睡眠比健康对照组浅。
结论
PPO在NREM睡眠中出现，尤其是在N3中，这表明上气道梗阻在深度睡眠中并不总是改善，而是改变了类型。即使PPO + OSA患者有N3睡眠，他们在三个EEG位置的NREM睡眠也较浅。这可能反映了睡眠恢复功能受损。
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