Wang Lu, Su Hong-Jun, Qi Jin-Long, E Rui-Fang, Zhao Kun
Department of Neurology, Tianjin Baodi Hospital, Tianjin, China.
J Int Med Res. 2018 Aug;46(8):3411-3416. doi: 10.1177/0300060518776570. Epub 2018 May 28.
Autoantibodies targeting aquaporin 4 (AQP4) water channels are a sensitive and specific biomarker for neuromyelitis optica spectrum disorder (NMOSD). Presence of AQP4 antibodies distinguishes NMOSD from multiple sclerosis. We present our experience with an anti-AQP4 antibody-positive patient diagnosed with NMOSD who complained of intractable nausea and vomiting, not restricted to optic neuritis or acute myelitis during the first attack. Her symptoms partially resolved after appropriate therapy with intravenous methylprednisolone and oral prednisolone. Through this case, we hope to draw attention to an unusual neurological presentation of NMOSD which should be included in the differential diagnosis of intractable nausea and vomiting.
靶向水通道蛋白4（AQP4）水通道的自身抗体是视神经脊髓炎谱系障碍（NMOSD）的一种敏感且特异的生物标志物。AQP4抗体的存在可将NMOSD与多发性硬化区分开来。我们介绍了一位抗AQP4抗体阳性且被诊断为NMOSD的患者的情况，该患者主诉顽固性恶心和呕吐，首次发作时不限于视神经炎或急性脊髓炎。经静脉注射甲泼尼龙和口服泼尼松龙进行适当治疗后，她的症状部分得到缓解。通过这个病例，我们希望引起人们对NMOSD一种不寻常神经表现的关注，这种表现应纳入顽固性恶心和呕吐的鉴别诊断中。
