Tsagakis Konstantinos, Wendt Daniel, Dimitriou Alexandros M, Thielmann Matthias, Shehada Sharaf-Eldin, El Gabry Mohamed, Jakob Heinz G
Department of Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center Essen, University of Duisburg-Essen, Essen, Germany -
Department of Thoracic and Cardiovascular Surgery, West German Heart and Vascular Center Essen, University of Duisburg-Essen, Essen, Germany.
J Cardiovasc Surg (Torino). 2018 Aug;59(4):540-546. doi: 10.23736/S0021-9509.18.10597-0. Epub 2018 May 25.
Frozen elephant trunk (FET) is considered to be the treatment of choice in complex multi-segmental thoracic aortic disease involving the distal arch. Institutional results of FET technique are presented.
From January 2005 to October 2017, 286 patients underwent FET surgery in our department. Patients (mean age 59±11 years) were operated for acute type I (55%) aortic dissection (AD), chronic AD (23%) and aneurysm (22%). Arch repair was performed with the E-vita Open prosthesis under with selective cerebral perfusion and hypothermic circulatory arrest. Zone 2 arch repair was applied in combination with debranching of the left subclavian artery. Redo-surgery after previous sternotomy underwent 52 patients.
Distal FET was moved from Zone 3 (36%) to Zone 2 (64%) during the past 10 years. Thirty-day mortality was 11% and similar in patients after first or redo-sternotomy (P=1.000). Proximalization of the anastomosis in Zone 2 improved permanent cerebral (4% vs. 8%, P=0.285) as wells as spinal events (2% vs. 4%, P=0.256) though not yet statistically significant. However, postoperative renal (26% vs. 43%, P=0.004) and pulmonary failure (19% vs. 42%, P<0.001) could be decreased significantly. Five-year survival was 75% and also improved with Zone 2 arch repair (P=0.022). Distal aortic arch pathology was excluded in all but one patient. Freedom from re-intervention downstream was 81% and was improved in acute AD compared to chronic AD and aneurysm (P=0.001). Not a single endoleak type I was encountered with this surgical-endovascular approach.
FET is the surgical treatment option of choice to achieve lasting results down to the stent-graft end for all comers with all kinds of arch disease and facilitates additional endovascular or surgical treatment downstream, if required. FET in combination with debranching enabling Zone 2 arch repair improved the results. However, FET remains major surgery and less invasive techniques including complete endovascular arch repair methods are welcome to increase our treatment armamentarium especially in frail multi-morbid patients.
对于累及主动脉弓远端的复杂多节段胸主动脉疾病,冷冻象鼻技术(FET)被认为是首选治疗方法。本文介绍了FET技术的机构治疗结果。
2005年1月至2017年10月,我科对286例患者实施了FET手术。患者平均年龄59±11岁,手术治疗急性I型主动脉夹层(AD)(55%)、慢性AD(23%)和动脉瘤(22%)。采用E-vita Open人工血管在选择性脑灌注和低温循环停搏下进行主动脉弓修复。2区主动脉弓修复联合左锁骨下动脉去分支术。52例患者曾接受过胸骨切开术,此次为再次手术。
在过去10年中,远端FET植入位置从3区(36%)转移至2区(64%)。30天死亡率为11%,首次胸骨切开术和再次胸骨切开术患者的死亡率相似(P = 1.000)。2区吻合口近端化改善了永久性脑事件(4% 对8%,P = 0.285)以及脊髓事件(2% 对4%,P = 0.256),尽管尚未达到统计学显著差异。然而,术后肾功能衰竭(26% 对43%,P = 0.004)和呼吸衰竭(19% 对42%,P < 0.001)可显著降低。5年生存率为75%,2区主动脉弓修复也使其有所提高(P = 0.022)。除1例患者外,所有患者均排除了主动脉弓远端病变。支架移植物下游免于再次干预的比例为81%,与慢性AD和动脉瘤相比,急性AD患者的这一比例有所提高(P = 0.001)。采用这种手术 - 血管腔内联合方法未出现1例I型内漏。
对于所有类型的主动脉弓疾病患者,FET是一种能实现支架移植物末端持久疗效的手术治疗选择,如有需要,还便于进行额外的血管腔内或手术治疗。FET联合去分支术实现2区主动脉弓修复可改善治疗结果。然而,FET仍是大手术,欢迎采用包括完全血管腔内主动脉弓修复方法在内的侵入性较小的技术,以增加我们的治疗手段,尤其是针对体弱多病的患者。