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手部部分移植:尸体解剖研究的经验教训

Partial Hand Transplant: Lessons Learned From Cadaveric Dissection Studies.

作者信息

Shubinets Valeriy, McAndrew Christine, Mauch Jaclyn, Glennon Alyssa Ricker, Kovach Stephen J, Gray Benjamin L, Steinberg David R, Bozentka David J, Lantieri Laurent, Chang Benjamin, Levin L Scott, Lin Ines C

机构信息

Department of Surgery, Division of Plastic Surgery, University of Pennsylvania, Philadelphia, PA.

Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA.

出版信息

J Hand Surg Am. 2018 Jul;43(7):634-640. doi: 10.1016/j.jhsa.2018.04.031. Epub 2018 May 25.

Abstract

As the field of vascularized composite allotransplantation continues to expand, new upper extremity transplant candidates are being considered. We recently evaluated a bilateral amputee who had a mid-forearm amputation and a contralateral metacarpal hand amputation. In the latter limb, a "partial" hand transplant that preserved the majority of the patient's existing hand, including a partially severed thumb with intact thenar muscle function, was proposed. The feasibility of this partial hand transplant was studied in fresh-frozen cadaver limbs. This report details the proposed approach, the cadaveric dissections, and the lessons learned from these dissections. Issues of osteosynthesis, microvascular planning, and intrinsic muscle recovery are discussed, all of which are critical considerations for partial hand transplant candidates. Ultimately, the partial hand approach was felt to be inferior to a more conventional distal forearm transplant in this particular candidate. Practical, functional, and ethical implications of such decision are presented.

摘要

随着血管化复合组织异体移植领域的不断扩展,新的上肢移植候选者正在被纳入考虑范围。我们最近评估了一名双侧截肢患者,其一侧为前臂中段截肢,另一侧为掌骨手部截肢。对于后一侧肢体,我们提出了一种“部分”手部移植方案,该方案保留了患者现有手部的大部分结构,包括一个部分离断但大鱼际肌功能完好的拇指。我们在新鲜冷冻的尸体肢体上研究了这种部分手部移植的可行性。本报告详细介绍了所提议的方法、尸体解剖情况以及从这些解剖中吸取的经验教训。文中讨论了骨合成、微血管规划和固有肌恢复等问题,这些都是部分手部移植候选者的关键考虑因素。最终,在这个特定的候选者身上,部分手部移植方法被认为不如更传统的前臂远端移植。本文还阐述了这一决定的实际、功能和伦理意义。

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