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有或无高血压家族史的血压正常受试者在进行身体应激测试时人体测量参数及血压变化的比较

Comparison of Anthropometric Parameters and Blood Pressure Changes in Response to Physical Stress Test in Normotensive Subjects with or Without Family History of Hypertension.

作者信息

Pardeshi Amita M, Kirtikar Sunanda N

出版信息

Indian J Physiol Pharmacol. 2016 Apr;60(2):208-212.

Abstract

Hypertension is recognized as a key risk factor for cardiovascular disease mortality and morbidity. Early detection of prehypertensive stage may help an individual to lead a healthy life by altering the life style. The present study was attempted to compare blood pressure response and anthropometric parameter in children of hypertensive and non hypertensive parents. The study was conducted on total 120 participants, 60 in control and 60 in test group. Cardiovascular response to stress was determined by Harvard step test. Heart rate (HR) and blood pressure response to exercise were measured in supine position before exercise and at 1, 2, 3, 4, 5, 7 and 10 minutes after the exercise. The results were expressed as Mean±SD and analyzed using Independent t- test (unpaired t-test) for comparison between the control group and the test group and one way ANOVA test. The "P" value < 0.05 was considered statistically significant. In the present study, body mass index (BMI), waist hip ratio (WHR) and waist circumference (WC) were found to be significantly higher in normotensive individuals with family history of hypertension. Stress induced changes in systolic blood pressure SBP), diastolic blood pressure (DBP), heart rate (HR) were found to be significantly higher in normotensive individuals with family history of hypertension as compared to normotensive individuals without family history of hypertension. The increased blood pressure and heart rate observed in the individual of hypertensive parents emphasizes the importance of genetic influence on hypertension. This blood pressure elevation may be considered as a permanent abnormality characterizing a prehypertensive stage early in life.

摘要

高血压被认为是心血管疾病死亡率和发病率的关键风险因素。早期发现高血压前期阶段可能有助于个体通过改变生活方式过上健康的生活。本研究试图比较有高血压家族史和无高血压家族史儿童的血压反应和人体测量参数。该研究共对120名参与者进行,其中对照组60人,试验组60人。通过哈佛台阶试验确定心血管对压力的反应。在运动前仰卧位以及运动后1、2、3、4、5、7和10分钟测量心率(HR)和运动后的血压反应。结果以均值±标准差表示,并使用独立t检验(非配对t检验)进行分析,以比较对照组和试验组,并进行单因素方差分析。“P”值<0.05被认为具有统计学意义。在本研究中,发现有高血压家族史的血压正常个体的体重指数(BMI)、腰臀比(WHR)和腰围(WC)显著更高。与无高血压家族史的血压正常个体相比,有高血压家族史的血压正常个体中,压力诱导的收缩压(SBP)、舒张压(DBP)、心率(HR)变化显著更高。在有高血压家族史个体中观察到的血压和心率升高强调了遗传因素对高血压的影响。这种血压升高可被视为生命早期高血压前期阶段的一种永久性异常特征。

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