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[疼痛与内啡肽]

[Pain and endorphins].

作者信息

van Ree J M

出版信息

Tijdschr Diergeneeskd. 1985 Jan 1;110(1):3-11.

PMID:2982220
Abstract

Various stimuli may evoke the symptom pain. These stimuli activate sensory receptors and this information is transmitted to the spinal cord and a number of cerebral centres. Various endogenous analgesic systems are present in the body, which can modulate and control the consequences of pain stimuli to some extent. Endogenous morphine-like substances (endorphins) are an essential factor in some of these systems. Endorphins may be released in the body during stress or by acupuncture and other pain-relieving procedures (e.g. the twitch in horses). The significance of endorphins is not confined to pain, but they are also involved in reward systems of the brain may therefore play a role in eating, sexual, social and addictive behaviour among others.

摘要

多种刺激可能引发疼痛症状。这些刺激激活感觉受体,该信息被传递至脊髓和多个脑中枢。体内存在多种内源性镇痛系统,它们可在一定程度上调节和控制疼痛刺激的后果。内源性吗啡样物质(内啡肽)是其中一些系统的重要因素。内啡肽可能在应激期间于体内释放,或通过针灸及其他止痛程序(如马匹的抽搐)释放。内啡肽的意义不仅限于疼痛,它们还参与大脑的奖赏系统,因此可能在饮食、性行为、社交及成瘾行为等方面发挥作用。

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