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[小细胞肺癌治疗的当前观点]

[Current perspectives in the management of small cell lung cancer].

作者信息

Fujita J, Saijo N

出版信息

Gan No Rinsho. 1985 Jan;31(1):1-19.

PMID:2984443
Abstract

Considerable progress has been made within the last decade in the management of small cell lung cancer (SCLC) resulting in prolongation of median survival by 4 to 5 times (about 14 and 9 months in limited and extensive disease, respectively), improved quality of life, and an increase of cure rates in 15 approximately 20% of the patients with limited disease. In this review, we are focusing on the details in update treatment schedules of combination chemotherapy against SCLC, prognostic features and staging of SCLC, the role of non-cross resistant alternating chemotherapy, radiotherapy to the primary site including hilar and mediastinal lymph nodes, prophylactic cranial irradiation and surgery in the treatment of SCLC, as well as the complications of treatment.

摘要

在过去十年中,小细胞肺癌(SCLC)的治疗取得了显著进展,使中位生存期延长了4至5倍(局限性和广泛性疾病分别约为14个月和9个月),提高了生活质量,并且使约15%至20%的局限性疾病患者的治愈率有所提高。在本综述中,我们将重点关注小细胞肺癌联合化疗最新治疗方案的细节、小细胞肺癌的预后特征和分期、非交叉耐药交替化疗的作用、包括肺门和纵隔淋巴结在内的原发部位放疗、预防性颅脑照射和手术在小细胞肺癌治疗中的应用,以及治疗的并发症。

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