肿瘤大小小于或等于2cm的老年浸润性肺腺癌患者行局限性切除与肺叶切除的预后
Prognosis of limited resection versus lobectomy in elderly patients with invasive lung adenocarcinoma with tumor size less than or equal to 2 cm.
作者信息
Chen Tianxiang, Luo Jizhuang, Wang Rui, Gu Haiyong, Gu Yu, Huang Qingyuan, Wang Yiyang, Zheng Jiajie, Yang Yunhai, Zhao Heng
机构信息
Shanghai Lung Cancer Center, Shanghai Chest Hospital, Shanghai Jiao Tong University, Shanghai 200030, China.
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325000, China.
出版信息
J Thorac Dis. 2018 Apr;10(4):2231-2239. doi: 10.21037/jtd.2018.04.47.
Abstract
BACKGROUND
This study aimed to evaluate the prognostic difference between limited resection and lobectomy among elderly patients with small size lung adenocarcinoma.
METHODS
A total of 666 patients >65 years old with stage I lung adenocarcinoma and tumor size ≤2 cm were included. The patient survival was evaluated by disease-free survival (DFS) and overall survival (OS). No DFS or OS advantage was found between the lobectomy and wedge resection groups when tumor sizes were ≤1 cm (DFS, P=0.112; OS, P=0.294). The wedge resection group had a significantly worse OS (P=0.041) than that in the lobectomy group when tumor sizes were >1 cm and ≤2 cm.
CONCLUSIONS
We conclude that wedge resection may be a reasonable surgical choice for elderly patients with tumor sizes ≤1 cm.
摘要
背景
本研究旨在评估老年小尺寸肺腺癌患者行局限性切除与肺叶切除的预后差异。
方法
纳入666例年龄>65岁、Ⅰ期肺腺癌且肿瘤大小≤2 cm的患者。通过无病生存期（DFS）和总生存期（OS）评估患者生存情况。当肿瘤大小≤1 cm时，肺叶切除组和楔形切除组之间未发现DFS或OS优势（DFS，P = 0.112；OS，P = 0.294）。当肿瘤大小>1 cm且≤2 cm时，楔形切除组的OS明显差于肺叶切除组（P = 0.041）。
结论
我们得出结论，对于肿瘤大小≤1 cm的老年患者，楔形切除可能是一种合理的手术选择。
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