Lute Sushma V, Dhenge Ranjit M, Salman Agba D
Department of Chemical and Biological Engineering, University of Sheffield, Mappin Street, Sheffield S1 3JD, UK.
Pharmaceutics. 2018 Jun 1;10(2):67. doi: 10.3390/pharmaceutics10020067.
This paper focuses on investigating the influence of varying barrel fill levels on the mean residence time, granule properties (median size, size distribution, and shape), and tensile strength of tablets. Specific feed load (SFL) (powder feed rate divided by screw speed) and powder feed number (PFN) (i.e., powder mass flow rate divided by the product of screw speed, screw diameter, and the material density in the denominator) were considered as surrogates for the barrel fill level. Two type of powders (lactose and microcrystalline cellulose (MCC)) were granulated separately at varying fill levels at different liquid-to-solid ratios (L/S). It was observed that by controlling the barrel fill level, the granule size, shape, and tablet tensile strength can be maintained at specific L/S. It was also noticed that the mean residence time decreased with increasing fill levels in the case of both lactose and MCC powder. However, it was only found to be related to the change in granule size in case of granulating microcrystalline cellulose at varying fill levels. At very high fill levels, granule size decreased, owing to a limited interaction between MCC powder and liquid at high throughput force and short residence time.
本文着重研究不同料筒填充水平对平均停留时间、颗粒性质（中位尺寸、尺寸分布和形状）以及片剂抗张强度的影响。将比进料负荷（SFL）（粉末进料速率除以螺杆转速）和进料次数（PFN）（即粉末质量流速除以螺杆转速、螺杆直径与分母中物料密度的乘积）视为料筒填充水平的替代指标。两种类型的粉末（乳糖和微晶纤维素（MCC））分别在不同的液固比（L/S）下以不同的填充水平进行制粒。结果表明，通过控制料筒填充水平，在特定的L/S下可以保持颗粒尺寸、形状和片剂抗张强度。还注意到，对于乳糖和MCC粉末，平均停留时间均随填充水平的增加而降低。然而，仅发现在不同填充水平下对微晶纤维素进行制粒时，平均停留时间与颗粒尺寸的变化有关。在非常高的填充水平下，由于在高通量力和短停留时间下MCC粉末与液体之间的相互作用有限，颗粒尺寸减小。
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