Nakajima Takanori
Department of Clinical Pharmaceutics, Nihon Pharmaceutical University.
Yakugaku Zasshi. 2018;138(6):763-766. doi: 10.1248/yakushi.17-00184-3.
Hospital preparations (HPs) prepared by hospital pharmacists have contributed to advanced medical care which is custom tailored to various and individual medical needs. Advanced pharmaceutical knowledge and skills are needed to properly prepare HPs. Hospital pharmacists have inherited formulations and the skills to prepare them from their predecessors. However, there has been an ongoing decrease in the number of HPs prepared in hospitals due to an increase in the availability of commercial formulations. Despite this trend, it is not acceptable for hospital pharmacists to lack experience when a doctor requests an original HP. We often refer to "The Hospital Preparation Casebook" when HPs are prepared. However, evidence for drug management and clinical evaluation of HPs in the book are frequently insufficient; it is difficult to keep the information up to date. Therefore, we consider that it is the role of universities to support the supply and usage of HPs in cooperation with hospital pharmacists and pharmacies. Here we report a trial that adopted a physicopharmaceutical approach to developing a HP of a mianserin hydrochloride suppository.
医院药剂师制备的医院制剂(HPs)有助于提供针对各种个体医疗需求定制的先进医疗服务。正确制备医院制剂需要先进的药学知识和技能。医院药剂师从其前辈那里继承了制剂配方及其制备技能。然而,由于市售制剂供应增加,医院制备的医院制剂数量一直在下降。尽管有这种趋势,但当医生要求提供原创医院制剂时,医院药剂师缺乏经验是不可接受的。我们在制备医院制剂时经常参考《医院制剂案例手册》。然而,该书中关于医院制剂药物管理和临床评估的证据常常不足;难以保持信息的时效性。因此,我们认为大学有责任与医院药剂师和药房合作,支持医院制剂的供应和使用。在此,我们报告一项采用物理药剂学方法开发盐酸米安色林栓剂医院制剂的试验。