Laboratory Breeding Base of Green Pesticide and Agricultural Bioengineering, Key Laboratory of Green Pesticide and Agricultural Bioengineering, Ministry of Education , Guizhou University , Huaxi District, Guiyang 550025 , China.
Department of Chemistry , University of Pavia , Pavia 27100 , Italy.
Org Lett. 2018 Jun 15;20(12):3447-3450. doi: 10.1021/acs.orglett.8b01029. Epub 2018 Jun 4.
A kinetic resolution of 1,2-diols bearing both a secondary and a primary alcohol motif through an N-heterocyclic carbene-catalyzed oxidative acylation reaction has been developed. A site- and enantioselective esterification reaction is involved for this process. Both the monoacylated diols obtained and the remaining enantioenriched 1,2-diols are versatile building blocks for the preparation of functional molecules with proven biological activities.
通过 N-杂环卡宾催化的氧化酰化反应，对同时带有仲醇和伯醇结构的 1,2-二醇进行了动力学拆分。该过程涉及到一个位点和对映选择性酯化反应。所得到的单酰化二醇以及剩余的对映体富集的 1,2-二醇都是多功能的构建块，可用于制备具有已证明生物活性的功能分子。
