抗动脉粥样硬化药物的免疫调节活性：对免疫复合物介导的细胞增殖、体液反应、迟发型超敏反应及被动过敏反应的影响。

Immunomodulatory activity of anti-atherogenic drugs: effects on blastogenesis, humoral response, delayed hypersensitivity and passive anaphylaxis by immune complexes.

作者信息

Rojo J M, Portolés M P, Ojeda G, Portolés A

出版信息

Immunopharmacology. 1985 Apr;9(2):109-16. doi: 10.1016/0162-3109(85)90006-2.

Abstract

The effect of several anti-atherogenic drugs (ticlopidine, nicotinic acid and etofibrate) on immune responses and immune complex anaphylaxis has been studied in mice. All the drugs enhanced the activation by concanavalin A, phytohemagglutinin, and lipopolysaccharide of lymphocytes taken from treated animals. Contact hypersensitivity to trinitrochlorobenzene was inhibited by similar treatments with the same drugs, possibly through inhibition of the efferent phase of the reaction. Nicotinic acid produced a slight enhancement of antibody responses to sheep erythrocytes, whereas etofibrate inhibited the response at the highest dose studied. In addition, treatment with these drugs variably protected the mice from anaphylactic shocks induced by immune complexes. Marked protection was also observed using the antiserotoninic, cyproheptadine. These results indicate that drugs used to prevent atherogenic processes modulate different proliferative and effector immunological reactions.

摘要

已在小鼠中研究了几种抗动脉粥样硬化药物（噻氯匹定、烟酸和益多酯）对免疫反应和免疫复合物过敏反应的影响。所有药物均增强了来自经治疗动物的淋巴细胞对刀豆球蛋白A、植物血凝素和脂多糖的活化作用。用相同药物进行类似处理可抑制对三硝基氯苯的接触性超敏反应，这可能是通过抑制反应的传出阶段实现的。烟酸对绵羊红细胞的抗体反应有轻微增强作用，而益多酯在研究的最高剂量下抑制了该反应。此外，用这些药物治疗可不同程度地保护小鼠免受免疫复合物诱导的过敏性休克。使用抗血清素药物赛庚啶也观察到了明显的保护作用。这些结果表明，用于预防动脉粥样硬化过程的药物可调节不同的增殖性和效应性免疫反应。