Naito Ryo, Miyauchi Katsumi, Nojiri Shuko, Suzuki Norihiro, Daida Hiroyuki
Department of Cardiovascular Medicine, Juntendo University School of Medicine, Japan.
Clinical Research Support Center, Juntendo University School of Medicine, Japan.
Intern Med. 2018 Nov 15;57(22):3233-3240. doi: 10.2169/internalmedicine.1020-18. Epub 2018 Jun 6.
Objective Coronary artery and cerebrovascular disease are the main causes of non-communicable diseases. In particular, acute coronary syndrome (ACS) and ischemic stroke are the most serious conditions of coronary artery disease and cerebrovascular disease, respectively. Therefore, it is important to prevent these conditions by identifying populations at high risk of these diseases. We sought to investigate the differences in the clinical features of patients with these atherothrombotic diseases in nationwide Japanese multicenter registries. Gender differences were also examined. Methods The dataset of the two nationwide multicenter registries for ACS [Prevention of AtherothrombotiC Incidents Following Ischemic Coronary (PACIFIC)] and ischemic stroke [Effective Vascular Event REduction after STroke (EVEREST)] was analyzed. Clinical features were examined and compared using datasets from the two registries. Results A total of 6,878 patients (PACIFIC: n=3,426, EVEREST: n=3,452) were evaluated. The patients' background characteristics were significantly different between the two populations. Patients with ACS tended to be younger, had a higher body mass index, had a greater prevalence of diabetes mellitus and dyslipidemia, were current smokers, and more often had a prior history of ischemia heart disease than patients with a stroke. Hypertension was more prevalent in patients with stroke than in those with ACS. The differences in patients' background characteristics between ACS and stroke in men were similar to those in the whole sample. However, the prevalence of hypertension in women was similar between the ACS and stroke groups, in contrast to the results from the whole sample. Conclusion Patients' background characteristics were significantly different between those with ACS and stroke. Gender differences were also observed.
目的 冠状动脉疾病和脑血管疾病是非传染性疾病的主要病因。特别是，急性冠状动脉综合征（ACS）和缺血性中风分别是冠状动脉疾病和脑血管疾病最严重的情况。因此，通过识别这些疾病的高危人群来预防这些情况很重要。我们试图在全国性的日本多中心登记处调查这些动脉粥样硬化血栓形成疾病患者的临床特征差异。还检查了性别差异。方法 分析了两个全国性多中心登记处关于ACS[缺血性冠状动脉事件后的动脉粥样硬化血栓形成预防（PACIFIC）]和缺血性中风[中风后有效血管事件减少（EVEREST）]的数据集。使用两个登记处的数据集检查并比较临床特征。结果 共评估了6878例患者（PACIFIC：n = 3426，EVEREST：n = 3452）。两组人群的患者背景特征有显著差异。与中风患者相比，ACS患者往往更年轻，体重指数更高，糖尿病和血脂异常的患病率更高，是当前吸烟者，并且更常有缺血性心脏病病史。高血压在中风患者中的患病率高于ACS患者。男性ACS和中风患者的背景特征差异与整个样本相似。然而，与整个样本的结果相反，ACS组和中风组女性的高血压患病率相似。结论 ACS患者和中风患者的背景特征有显著差异。也观察到了性别差异。
