多巴胺、乙酰胆碱和γ-氨基丁酸在迟发性运动障碍发生发展中的作用的新观点。

New aspects on the role of dopamine, acetylcholine, and GABA in the development of tardive dyskinesia.

作者信息

Scheel-Krüger J, Arnt J

出版信息

Psychopharmacology Suppl. 1985;2:46-57. doi: 10.1007/978-3-642-70140-5_6.

Abstract

In this paper various new findings on the possible anatomical substrates of tardive dyskinesia will be presented. The results show that the striatum is heterogeneously organized, and the syndromes of biting, gnawing, and licking activities in the rat model involve a complex balance between various dopamine (DA), cholinergic, and GABAergic systems within the striatum and the mesolimbic and mesocortical systems.

摘要

本文将展示关于迟发性运动障碍可能的解剖学基础的各种新发现。结果表明，纹状体组织具有异质性，大鼠模型中的咬、啃和舔舐活动综合征涉及纹状体内以及中脑边缘系统和中脑皮质系统中各种多巴胺（DA）、胆碱能和γ-氨基丁酸能（GABAergic）系统之间的复杂平衡。