正常体重儿童和青少年人体测量指标与心血管代谢危险因素的关联：CASPIAN-V研究
Association of anthropometric measures and cardio-metabolic risk factors in normal-weight children and adolescents: the CASPIAN-V study.
作者信息
Ahadi Zeinab, Bahreynian Maryam, Qorbani Mostafa, Heshmat Ramin, Motlagh Mohammad Esmaeil, Shafiee Gita, Gorabi Armita Mahdavi, Ziaodini Hasan, Taheri Majzoubeh, Aminaei Tahereh, Kelishadi Roya
机构信息
Chronic Diseases Research Center, Endocrinology and Metabolism Population Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran.
Pediatrics Department, Child Growth and Development Research Center, Research Institute for Primordial Prevention of Non-communicable Disease, Isfahan University of Medical Sciences, Isfahan, Iran.
出版信息
J Pediatr Endocrinol Metab. 2018 Aug 28;31(8):847-854. doi: 10.1515/jpem-2018-0018.
BACKGROUND
The present study aims to explore the association of anthropometric indices and cardio-metabolic risk factors in normal-weight children and adolescents.
METHODS
This cross-sectional nationwide study was conducted in 2015 among 4200 Iranian school students aged 7-18 years. They were selected using a multi-stage cluster random sampling method. Anthropometric indices and cardio-metabolic risk factors including fasting blood glucose (FBG), lipid profile and blood pressure (BP) were measured using standard protocols.
RESULTS
The response rate was 91.5%. Systolic blood pressure (SBP) and diastolic blood pressure (DBP) had a significant positive correlation with waist circumference (WC), hip circumference (HC) and body mass index (BMI) in boys and girls. HDL-C had a significant inverse correlation with WC, HC and BMI in boys. For each unit increase in WC, HC and BMI, the risk of elevated DBP significantly increased by 2%, 1% and 11%, respectively. Likewise, for each unit increase in WC, HC and BMI, the risk of elevated BP significantly raised by 2%, 1% and 10%, respectively. For each unit increase in WC, the risk of metabolic syndrome increased by 7%.
CONCLUSIONS
Anthropometric indices are considered an easy, non-invasive tool for the prediction of cardio-metabolic risk factors in normal-weight children and adolescents.
背景
本研究旨在探讨正常体重儿童和青少年的人体测量指标与心血管代谢风险因素之间的关联。
方法
2015年在伊朗全国范围内对4200名7至18岁的在校学生进行了这项横断面研究。采用多阶段整群随机抽样方法选取研究对象。使用标准方案测量人体测量指标和心血管代谢风险因素，包括空腹血糖（FBG）、血脂谱和血压（BP）。
结果
应答率为91.5%。男孩和女孩的收缩压（SBP）和舒张压（DBP）与腰围（WC）、臀围（HC）和体重指数（BMI）均呈显著正相关。男孩的高密度脂蛋白胆固醇（HDL-C）与WC、HC和BMI呈显著负相关。WC、HC和BMI每增加一个单位，DBP升高的风险分别显著增加2%、1%和11%。同样，WC、HC和BMI每增加一个单位，BP升高的风险分别显著增加2%、1%和10%。WC每增加一个单位，代谢综合征的风险增加7%。
结论
人体测量指标被认为是预测正常体重儿童和青少年心血管代谢风险因素的一种简单、无创的工具。
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