du Toit Therina, Finken Martijn J J, Hamer Henrike M, Heijboer Annemieke C, Swart Amanda C
Department of Biochemistry, Stellenbosch University, Stellenbosch, South Africa.
Department of Pediatric Endocrinology, VU University Medical Center, Amsterdam, The Netherlands.
Steroids. 2018 Oct;138:1-5. doi: 10.1016/j.steroids.2018.06.003. Epub 2018 Jun 6.
The purpose of this study was to identify the C11-oxy C and C11-oxy C steroids in male and female neonate plasma. At birth, the most abundant C11-oxy steroids detected in neonatal plasma were 11β-hydroxyandrostenedione, ∼13 nM, and 11-ketoprogesterone, ∼23 nM. C11-oxy C steroids were higher than C steroids in neonatal plasma, 22.2 nM vs 5.4 nM. The inclusion of C11-oxy C and C steroid reference ranges in routine steroid analyses will assist the characterization of disorders associated with impaired steroidogenic enzyme expression and the identification of potential biomarkers.
本研究的目的是鉴定男性和女性新生儿血浆中的C11-氧代C和C11-氧代C类固醇。出生时，新生儿血浆中检测到的最丰富的C11-氧代类固醇是11β-羟基雄烯二酮，约13 nM，以及11-酮孕酮，约23 nM。新生儿血浆中C11-氧代C类固醇高于C类固醇，分别为22.2 nM和5.4 nM。在常规类固醇分析中纳入C11-氧代C和C类固醇参考范围将有助于对与类固醇生成酶表达受损相关的疾病进行特征描述，并有助于识别潜在的生物标志物。
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