一项关于血啉甲醚光动力疗法治疗中国儿童鲜红斑痣患者的临床研究。
A clinical study of HMME-PDT therapy in Chinese pediatric patients with port-wine stain.
机构信息
Department of Dermatology, The Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of China Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.
Department of Dermatology, The Children's Hospital of Chongqing Medical University, Ministry of Education Key Laboratory of Child Development and Disorders, China International Science and Technology Cooperation base of China Development and Critical Disorders, Chongqing Key Laboratory of Pediatrics, Chongqing 400014, China.
出版信息
Photodiagnosis Photodyn Ther. 2018 Sep;23:102-105. doi: 10.1016/j.pdpdt.2018.06.006. Epub 2018 Jun 8.
OBJECTIVE
To report our observations from a trial of the effectiveness and safety of hematoporphyrin monomethyl ether photodynamic therapy (HMME-PDT) in treating Chinese Pediatric patients port-wine stains (PWS).
METHOD
From October 2017 to December 2017, the study recruited 82 patients of PWS with negative HMME skin test results. The patients received an intravenous injection of 5 mg/kg HMME and the affected areas were exposed to 532 nm LED green light, with the irradiation power density between 80-85 mW/cm. Each light spot was irradiated for 20-25 min. After two treatments, the clinical efficacy and posttreatment reactions at each treated area were observed.
RESULT
The patient age between 1 and 14 years old. 24 of the 82 cases were cured (29.27%) after two HMME-PDT treatment, 34 cases indicates a good efficacy (41.46%), 16 cases showed alleviation (19.51%), while 8 cases displayed no efficacy (9.76%). Pain was observed during treatment, and post-treatment edema was observed at the treated areas. No other obvious systematic adverse reaction were reported.
CONCLUSION
HMME-PDT is an effective and safe treatment for pediatric patients with PWS.
目的
报告我们使用血卟啉单甲醚光动力学疗法（HMME-PDT）治疗中国儿科鲜红斑痣（PWS）患者的有效性和安全性观察结果。
方法
2017 年 10 月至 2017 年 12 月，本研究共招募了 82 例 HMME 皮肤试验阴性的 PWS 患者。患者静脉注射 5mg/kg 的 HMME，受影响的区域暴露于 532nm 的 LED 绿光下，辐照功率密度在 80-85mW/cm 之间。每个光斑照射 20-25 分钟。两次治疗后，观察每个治疗区域的临床疗效和治疗后反应。
结果
患者年龄在 1 至 14 岁之间。82 例患者中有 24 例（29.27%）在两次 HMME-PDT 治疗后痊愈，34 例疗效良好（41.46%），16 例缓解（19.51%），8 例无效（9.76%）。治疗过程中观察到疼痛，治疗区域观察到治疗后水肿。未报告其他明显的系统性不良反应。
结论
HMME-PDT 是治疗儿科 PWS 患者的一种有效且安全的方法。
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