F-FDG PET/CT在前哨淋巴结阴性且Clark分级高的皮肤黑色素瘤患者中的应用价值

Usefulness of F-FDG PET/CT in Cutaneous Melanoma Patients with Negative Sentinel Lymph Nodes and High Clark Levels.

作者信息

Vural Topuz Özge, Görtan Fatma Arzu, Kaya Döner Zübeyde Rana, Önsel Çetin, Sayman Haluk Burçak

机构信息

University of Health Sciences, Okmeydanı Training and Research Hospital, Clinic of Nuclear Medicine, İstanbul, Turkey.

University of Health Sciences, Ankara Atatürk Training and Research Hospital, Clinic of Nuclear Medicine, Ankara, Turkey.

出版信息

Mol Imaging Radionucl Ther. 2018 Jun 7;27(2):66-72. doi: 10.4274/mirt.70783.

DOI:10.4274/mirt.70783

PMID:29889028

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5996600/

Abstract

OBJECTIVE

We investigated the utility of PET/CT in cutaneous melanoma (CM) patients with pathological negative sentinel lymph nodes (SLN), within the first year.

METHODS

The results of PET/CTs and SLN biopsy (SLNB) in 65 patients (39 male and 26 female, mean age 53.8) with a PET/CT in the first postoperative year were evaluated. Within this cohort, the utility of early PET/CT imaging was assessed in patients with negative SLNB. McNemar test was used to compare PET/CT findings with SLNB results.

RESULTS

Out of 43 patients with pathologically positive SLNs, 23 patients (53.5%) had positive and 20 patients (46.5%) had negative findings on PET/CT within the first postoperative year. On the other hand, PET/CT results of 22 patients with negative SLNBs were found to be negative in 19 patients (86.4%) and positive in 3 patients (13.6%). For the patients with negative SLNB results, the detection rate of distant metastasis with PET/CT was significantly lower (p<0.001) than that in patients with positive SLNBs.

CONCLUSION

Our results showed that F-FDG PET/CT will most likely (86.4%) be negative during the first postoperative year in patients with a negative SLNB. Therefore, it is concluded that this modality would not provide any significant clinical contribution within this time frame.

摘要

目的

我们研究了正电子发射断层扫描/计算机断层扫描（PET/CT）在术后第一年病理检查前哨淋巴结（SLN）为阴性的皮肤黑色素瘤（CM）患者中的应用价值。

方法

对65例（39例男性和26例女性，平均年龄53.8岁）在术后第一年接受PET/CT检查的患者的PET/CT和前哨淋巴结活检（SLNB）结果进行评估。在该队列中，对SLNB阴性的患者评估早期PET/CT成像的应用价值。采用McNemar检验比较PET/CT结果与SLNB结果。

结果

在43例病理检查前哨淋巴结阳性的患者中，23例（53.5%）在术后第一年内PET/CT检查结果为阳性，20例（46.5%）为阴性。另一方面，22例SLNB阴性患者的PET/CT结果显示，19例（86.4%）为阴性，3例（13.6%）为阳性。对于SLNB结果为阴性的患者，PET/CT检测远处转移的比率显著低于（p<0.001）SLNB结果为阳性的患者。