围手术期输血对胃癌患者预后的影响：单中心数据库的回顾性分析。
Effect of perioperative blood transfusion on prognosis of patients with gastric cancer: a retrospective analysis of a single center database.
机构信息
Department of Gastric Cancer Surgery, Fudan University Shanghai Cancer Center, 270 Dong An Road, Shanghai, 200032, People's Republic of China.
Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, 200032, China.
出版信息
BMC Cancer. 2018 Jun 11;18(1):649. doi: 10.1186/s12885-018-4574-4.
BACKGROUND
The association between perioperative blood transfusion and the prognosis of patients with gastric cancer is still unclear.
METHODS
A total of 1581 patients with gastric cancer who underwent curative gastrectomy from 2000 to 2008 were evaluated. Perioperative blood transfusion was defined as the transfusion of packed red blood cells within seven days before surgery, during surgery, or within the postoperative hospitalization period. The association between perioperative blood transfusion and prognosis was evaluated using univariate and multivariate Cox regression analyses.
RESULTS
Of 1581 patients, 298 patients (19%) received perioperative blood transfusion. Perioperative blood transfusion correlated with older age (P < 0.001); larger tumor size (P < 0.001); and more advanced stage (P < 0.001). Five-year survival rate was 40% in patients who had perioperative blood transfusion and 55% patients who did not have perioperative blood transfusion, and the difference was statistically significant (P < 0.001). Multivariate analysis showed that perioperative blood transfusion was defined as independent prognostic factor. Perioperative blood transfusion was associated with worse outcomes in patients with stage III (P < 0.001).
CONCLUSIONS
Perioperative blood transfusion independently correlated with poorer prognosis in patients with gastric cancer.
背景
围手术期输血与胃癌患者预后之间的关系尚不清楚。
方法
评估了 2000 年至 2008 年间接受根治性胃切除术的 1581 例胃癌患者。围手术期输血定义为术前 7 天内、手术期间或术后住院期间输注红细胞。使用单因素和多因素 Cox 回归分析评估围手术期输血与预后的关系。
结果
在 1581 例患者中，298 例（19%）接受了围手术期输血。围手术期输血与年龄较大（P<0.001）；肿瘤较大（P<0.001）；和更晚期的阶段（P<0.001）。接受围手术期输血的患者 5 年生存率为 40%，未接受围手术期输血的患者 5 年生存率为 55%，差异有统计学意义（P<0.001）。多因素分析表明，围手术期输血是独立的预后因素。围手术期输血与 III 期患者的预后较差相关（P<0.001）。
结论
围手术期输血与胃癌患者的预后不良独立相关。
Zotero 插件