Ruzicka T
Hautarzt. 1985 May;36(5):255-8.
The pros and cons concerning the involvement of arachidonic acid metabolism in the pathogenesis of psoriasis are presented. The isolation of arachidonic acid metabolites from psoriatic lesions, their extraordinary biological activity, and the therapeutic efficiency in psoriasis of inhibitors of arachidonic acid metabolism all argue in favor of leukotrienes and monohydroxy fatty acids playing an important role in the development of psoriasis plaques. On the other hand, the lack of specificity of the biochemical findings, the failure to reproduce psoriatic lesions by arachidonic acid metabolites, and the therapeutic activity of drugs that have no effect on arachidonic acid metabolism show that the role of arachidonic acid metabolism in the pathogenesis of psoriasis is still controversial. The availability of selective inhibitors of arachidonic acid-metabolizing enzymes for clinical testing is a prerequisite before pathophysiological conclusions can be made, as the present status of knowledge makes any conclusions premature.
本文介绍了花生四烯酸代谢参与银屑病发病机制的利弊。从银屑病皮损中分离出花生四烯酸代谢产物、它们非凡的生物活性以及花生四烯酸代谢抑制剂对银屑病的治疗效果，均表明白三烯和单羟基脂肪酸在银屑病斑块形成中起重要作用。另一方面，生化研究结果缺乏特异性、花生四烯酸代谢产物未能复制出银屑病皮损以及对花生四烯酸代谢无影响的药物具有治疗活性，表明花生四烯酸代谢在银屑病发病机制中的作用仍存在争议。在得出病理生理学结论之前，有可供临床测试的花生四烯酸代谢酶选择性抑制剂是必要前提，因为就目前的知识水平而言，任何结论都为时过早。
