双纳米颗粒在使用分光光度计的两种不同聚合物凝胶剂量计中剂量增强效应的应用。
Application of bi-nanoparticle on dose enhancement effect in two different polymer gel dosimeter using spectrophotometer.
作者信息
Sathiyaraj P, Jebaseelan Samuel E James
机构信息
Department of Physics, Medical Dosimetry Laboratory, School of Advanced Sciences, VIT-University, Vellore, Tamil Nadu, India.
Photonics, Nuclear and Medical Physics Division, VIT University, Vellore, Tamil Nadu, India.
出版信息
J Cancer Res Ther. 2018 Apr-Jun;14(3):662-665. doi: 10.4103/0973-1482.187295.
PURPOSE
This study aimed at proving the ability of bismuth-nanoparticle (Bi-np) in dose enhancement effect (DEE) using the polymer gel dosimeter. Two different polymer gels, namely poly acrylamide gelatin tetrakis hydroxymethyl phosphonium chloride (PAGAT) and N-isopropylacrylamide (NIPAM) gels were chosen for this study.
MATERIALS AND METHODS
The gels were doped with Bi-np particle with various concentrations of 0.5 mM, 1 mM, and 2.5 mM and were then irradiated with a CO-60 gamma radiation source of energy 1.25 MeV. Gel samples were analyzed by spectrophotometer. The dose enhancement factor (DEF) was calculated for both gels for all concentrations of Bi-np particle.
RESULTS
The higher DEF for PAGAT and NIPAM was calculated as 1.3415 and 1.1823, respectively, for 0.5 mM concentration of Bi-np.
CONCLUSION
From our results, we infer that 0.5 mM is the optimal concentration in polymer gel to obtain good DEEs in the energy range of 1.25 MeV.
目的
本研究旨在利用聚合物凝胶剂量计证明铋纳米颗粒（Bi-np）的剂量增强效应（DEE）能力。本研究选用了两种不同的聚合物凝胶，即聚丙烯酰胺明胶四羟甲基氯化鏻（PAGAT）和N-异丙基丙烯酰胺（NIPAM）凝胶。
材料与方法
将凝胶用浓度分别为0.5 mM、1 mM和2.5 mM的Bi-np颗粒进行掺杂，然后用能量为1.25 MeV的CO-60γ射线源进行照射。凝胶样品用分光光度计进行分析。计算了两种凝胶在所有Bi-np颗粒浓度下的剂量增强因子（DEF）。
结果
对于浓度为0.5 mM的Bi-np，PAGAT和NIPAM的较高DEF分别计算为1.3415和1.1823。
结论
根据我们的结果，我们推断0.5 mM是聚合物凝胶中的最佳浓度，以便在1.25 MeV的能量范围内获得良好的剂量增强效应。
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