Simoneti Luis Fernando, Weckwerth Giovana Maria, Dionísio Thiago José, Torres Elza Araujo, Zupelari-Gonçalves Paulo, Calvo Adriana Maria, Lauris José Roberto, Faria Flávio Cardoso, Santos Carlos Ferreira
Department of Biological Sciences, Bauru School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil.
Department of Pediatric Dentistry, Orthodontics and Community Health, Bauru School of Dentistry, USP - Universidade de São Paulo, Bauru, SP, Brazil.
Braz Dent J. 2018 Mar-Apr;29(2):140-149. doi: 10.1590/0103-6440201802254.
In view of the gastrointestinal problems generated by the ketoprofen use, the ketoprofen association with omeprazole is available on the market. However, this association efficacy in acute pain control has not been established. Bilateral extraction of lower third molars in similar positions is currently the most used model for the evaluation and investigation of the efficacy and pharmacological effects of new compounds for the treatment of acute postoperative pain. The randomized and crossover study consisted in evaluating the clinical efficacy of therapy performed by ketoprofen 100 mg (twice daily-b.i.d.) versus ketoprofen 200 mg + omeprazole 20 mg (once daily-q.d.) to pain, swelling and trismus control in the bilateral extraction model of lower third molars in similar positions in two different appointments, in 50 volunteers. Volunteers reported significantly less postoperative pain at various post-operative periods and consumed less rescue analgesic medication (acetaminophen 750 mg) throughout the study when they took the combination of ketoprofen 200 mg + omeprazole 20 mg (q.d.). Following administration of both study drugs, no gastrointestinal adverse reactions were reported by volunteers. Furthermore, the evaluations of the drugs in pain control by the volunteers were significantly favorable to ketoprofen 200 mg + omeprazole 20 mg (q.d.). For swelling and trismus control, the treatments presented similar results. In conclusion, when volunteers took ketoprofen 200 mg + omeprazole 20 mg (q.d.), they reported significantly less postoperative pain at various post-surgical periods and consumed less rescue analgesic medication throughout the study compared with ketoprofen 100 mg (b.i.d).
鉴于酮洛芬使用所产生的胃肠道问题，酮洛芬与奥美拉唑的组合已投放市场。然而，这种组合在控制急性疼痛方面的疗效尚未得到证实。双侧拔除相似位置的下颌第三磨牙是目前评估和研究治疗急性术后疼痛新化合物的疗效和药理作用时最常用的模型。这项随机交叉研究旨在评估100毫克酮洛芬（每日两次）与200毫克酮洛芬+20毫克奥美拉唑（每日一次）在两个不同时间段对50名志愿者双侧相似位置下颌第三磨牙拔除模型中的疼痛、肿胀和牙关紧闭控制的临床疗效。在整个研究过程中，当志愿者服用200毫克酮洛芬+20毫克奥美拉唑（每日一次）组合时，他们在术后不同时期报告的术后疼痛明显较少，且使用的急救镇痛药（750毫克对乙酰氨基酚）也较少。在服用两种研究药物后，志愿者均未报告胃肠道不良反应。此外，志愿者对药物在疼痛控制方面的评估明显倾向于200毫克酮洛芬+20毫克奥美拉唑（每日一次）。对于肿胀和牙关紧闭的控制，两种治疗方法结果相似。总之，与100毫克酮洛芬（每日两次）相比，当志愿者服用200毫克酮洛芬+20毫克奥美拉唑（每日一次）时，他们在术后不同时期报告的术后疼痛明显较少，且在整个研究过程中使用的急救镇痛药也较少。
