Ji Meiqi, Qin Yali, Zi Yingxin, Wang Rui, Meng Huan, Yang Zongchun, Zhao Qi, Jin Ming
Beijing University of Chinese Medicine Department of Ophthalmology, China-Japan Friendship Hospital, Beijing, China.
Medicine (Baltimore). 2018 Jun;97(24):e11065. doi: 10.1097/MD.0000000000011065.
Ophthalmoplegia is a disease that affects many people every year and is caused by reasons, such as cavernous sinus lesion, intracranial aneurysm, diabetes, and trauma. Acupuncture has been widely used to treat ophthalmological diseases especially ophthalmoplegia in China. Many clinical trials indicate that acupuncture may promote the recovery of extraocular muscles in ophthalmoplegia patients. We aim to conduct a meta-analysis to evaluate the efficacy and safety of acupuncture for ophthalmoplegia.
We will retrieve the literature from the following electronic databases, by March 31, 2018, such as PubMed, EMBASE, the Cochrane Library, Web of Science database, Chinese BioMedical Literature Database, China National Knowledge Infrastructure, China Science and Technology Journal database, and Wanfang Database. We will also collect clinical trial registries, dissertations, grey literature, reference lists of studies, systematic reviews, and conference abstracts. Two people will review these articles, extract the data information, and assess the quality of studies separately. Data will be synthesized by either fixed-effects or random-effects model regarding to a heterogeneity test. The eyeball movement distance, size of fissure palpebrae, and the reduced degree of strabismus will be assessed as the primary outcomes. The secondary outcomes will be the size of the pupil, main symptom scores, ocular localization analysis, and functional impairment extent and safety. We will use the specific software called RevMan (version 5.3) to perform the meta-analysis.
This study will provide a high-quality synthesis based on current evidence of acupuncture for ophthalmoplegia, especially its impacts on eyeball movement distance, size of fissure palpebrae, the reduced degree of strabismus, size of the pupil, main symptom scores, ocular localization analysis, and functional impairment extent and safety.
Our systematic review will provide evidence to determine whether acupuncture is an effective and safe intervention for ophthalmoplegia patients.
It is not necessary for this systematic review to acquire an ethical approval. This review will be disseminated in a peer-reviewed journal or conference presentation.
PROSPERO CRD42018091536.
每年有许多人受眼肌麻痹困扰，其病因包括海绵窦病变、颅内动脉瘤、糖尿病及外伤等。在中国，针灸已广泛用于治疗眼科疾病尤其是眼肌麻痹。多项临床试验表明，针灸可能促进眼肌麻痹患者眼外肌的恢复。我们旨在进行一项荟萃分析，以评估针灸治疗眼肌麻痹的疗效和安全性。
截至2018年3月31日，我们将从以下电子数据库检索文献，如PubMed、EMBASE、Cochrane图书馆、Web of Science数据库、中国生物医学文献数据库、中国知网、中国科技期刊数据库和万方数据库。我们还将收集临床试验注册信息、学位论文、灰色文献、研究的参考文献列表、系统评价和会议摘要。两人将分别审阅这些文章，提取数据信息并评估研究质量。根据异质性检验，采用固定效应或随机效应模型对数据进行合并。将眼球运动距离、睑裂大小及斜视减轻程度作为主要结局指标。次要结局指标将包括瞳孔大小、主要症状评分、眼部定位分析、功能损害程度及安全性。我们将使用名为RevMan（版本5.3）的特定软件进行荟萃分析。
本研究将基于当前针灸治疗眼肌麻痹的证据进行高质量的综合分析，尤其是其对眼球运动距离、睑裂大小、斜视减轻程度、瞳孔大小、主要症状评分、眼部定位分析、功能损害程度及安全性的影响。
我们的系统评价将为确定针灸对眼肌麻痹患者是否为有效且安全的干预措施提供证据。
本系统评价无需获得伦理批准。本评价将在同行评审期刊或会议报告中发表。
PROSPERO注册号：PROSPERO CRD42018091536。
