A simple method for studying chemotaxis, vascular permeability and histological modifications induced by mediators of inflammation in vivo in man.

A new method is described allowing the quantitative and kinetic analysis, in vivo in human skin, of the chemotaxis of inflammatory cells, of the modifications of vascular permeability and of the histological and cytological events induced by certain mediators of inflammation. In order to illustrate the usefulness of the method, the effects of chronic contact to human skin of two potent mediators of inflammation, LTB4 and Paf-acether, are described.