Zhang Yong, Lu Lu, Lu Nanhang, Yang Yanwen, Gu Jianying, Qi Fazhi
From the Department of Plastic and Reconstruction Surgery, Zhongshan Hospital, Fudan University, Shanghai, China.
Ann Plast Surg. 2018 Sep;81(3):302-304. doi: 10.1097/SAP.0000000000001534.
Long-term steroid therapy is associated with increased postoperative morbidity. Whether to use a stress dose of glucocorticoids (GCs) in surgical patients remains controversial. In the present study, we reported our experience in perioperative GC treatment of 6 patients on long-term steroid therapy for autoimmune diseases undergoing hand reconstruction using reversed interosseous flap.
The reversed interosseous flap reconstructions were performed after local extended resection of hand neoplasms. The patients were all diagnosed with autoimmune diseases and were undergoing long-term steroid therapy. Stress dose of GCs was not given in any case, and all the patients either remained on their baseline maintenance dose or decreased the dose until the morning of the operation day. Hypotension, water-electrolyte imbalance, hypoglycemia, and other symptoms of adrenal insufficiency were carefully assessed. Appearances of flap complications were recorded.
None of the patients developed hypotension or other symptomatic adrenal insufficiency. Flap infection, venous congestion, or complete or partial loss of flap was not observed in any patient. Effusion underneath the flap was developed in only 1 case and was solved by proper drainage.
It is safe, reliable, and versatile to use reversed interosseous flap to repair hand defects in patients on long-term steroid therapy. A stress dose of GCs might not be necessary in this procedure and other equally moderate soft tissue reconstructive surgeries.
长期使用类固醇治疗与术后发病率增加有关。外科手术患者是否使用应激剂量的糖皮质激素(GCs)仍存在争议。在本研究中,我们报告了对6例因自身免疫性疾病接受长期类固醇治疗的患者,使用逆行骨间皮瓣进行手部重建的围手术期GC治疗经验。
在手部肿瘤局部扩大切除后进行逆行骨间皮瓣重建。所有患者均被诊断为自身免疫性疾病且正在接受长期类固醇治疗。在任何情况下均未给予应激剂量的GCs,所有患者要么维持基线维持剂量,要么在手术当天早晨前减少剂量。仔细评估低血压、水电解质失衡、低血糖及其他肾上腺功能不全症状。记录皮瓣并发症的出现情况。
所有患者均未出现低血压或其他有症状的肾上腺功能不全。所有患者均未观察到皮瓣感染、静脉淤血或皮瓣完全或部分坏死。仅1例患者出现皮瓣下积液,经适当引流后得到解决。
对于长期接受类固醇治疗的患者,使用逆行骨间皮瓣修复手部缺损是安全、可靠且通用的。在此手术及其他同样程度的软组织重建手术中,可能无需使用应激剂量的GCs。