Faculty of Medicine, Transilvania University of Brasov, Nicolae Balcescu 56, 500019 Brasov, Romania.
Toxicology Unit, Research Institute of Biomedical and Health Sciences (IUIBS), Instituto Canario de Investigación del Cáncer (ICIC), Universidad de Las Palmas de Gran Canaria, Paseo Blas Cabrera Felipe s/n, 35016 Las Palmas de Gran Canaria, Spain.
Environ Res. 2018 Oct;166:269-275. doi: 10.1016/j.envres.2018.06.007. Epub 2018 Jun 13.
Smoking is considered an important source for inorganic elements, most of them toxic for human health. During the last years, there has been a significant increase in the use of e-cigarettes, although the role of them as source of inorganic elements has not been well established. A cross-sectional study including a total of 150 subjects from Brasov (Romania), divided into three groups (non-smokers, cigarette smokers and electronic cigarettes smokers) were recruited to disclose the role of smoking on the human exposure to inorganic elements. Concentration of 42 elements, including trace elements, elements in the ATSDR's priority pollutant list and rare earth elements (REE) were measured by ICP-MS in the blood serum of participants. Cigarette smokers showed the highest levels of copper, molybdenum, zinc, antimony, and strontium. Electronic cigarette (e-cigarette) users presented the highest concentrations of selenium, silver, and vanadium. Beryllium, europium and lanthanides were detected more frequently among e-cigarette users (20.6%, 23.5%, and 14.7%) than in cigarette smokers (1.7%, 19.0%, and 12.1%, respectively); and the number of detected REE was also higher among e-cigarette users (11.8% of them showed more than 10 different elements). Serum levels of cerium and erbium increased as the duration of the use of e-cigarettes was longer. We have found that smoking is mainly a source of heavy metals while the use of e-cigarettes is a potential source of REE. However, these elements were detected at low concentrations.
吸烟被认为是无机元素的重要来源，其中大多数对人体健康有毒。近年来，电子烟的使用显著增加，尽管它们作为无机元素来源的作用尚未得到充分证实。一项包括来自罗马尼亚布拉索夫的总共 150 名受试者的横断面研究，将受试者分为三组（非吸烟者、香烟吸烟者和电子烟吸烟者），以揭示吸烟对人体暴露于无机元素的影响。通过电感耦合等离子体质谱法（ICP-MS）在参与者的血清中测量了 42 种元素，包括微量元素、美国环保署优先污染物清单中的元素和稀土元素（REE）。香烟吸烟者的铜、钼、锌、锑和锶含量最高。电子烟使用者的硒、银和钒浓度最高。铍、铕和镧系元素在电子烟使用者中（20.6%、23.5%和 14.7%）比在香烟吸烟者中（1.7%、19.0%和 12.1%）更频繁地被检测到；电子烟使用者检测到的 REE 数量也更高（11.8%的人显示出超过 10 种不同的元素）。随着电子烟使用时间的延长，血清中铈和铒的水平增加。我们发现吸烟主要是重金属的来源，而电子烟的使用是 REE 的潜在来源。然而，这些元素的浓度较低。
