Max Planck Institute for Metabolism Research, 50931 Cologne, Germany; John B. Pierce Laboratory, New Haven, CT 06519, USA; Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06519, USA; Modern Diet and Physiology Research Center, New Haven, CT 06519, USA.
Max Planck Institute for Metabolism Research, 50931 Cologne, Germany; Swiss Center for Affective Sciences, Geneva 1202, Switzerland; E3 Lab, University of Geneva, Geneva 1205, Switzerland.
Cell Metab. 2018 Jul 3;28(1):33-44.e3. doi: 10.1016/j.cmet.2018.05.018. Epub 2018 Jun 14.
Post-ingestive signals conveying information about the nutritive properties of food are critical for regulating ingestive behavior. Here, using an auction task concomitant to fMRI scanning, we demonstrate that participants are willing to pay more for fat + carbohydrate compared with equally familiar, liked, and caloric fat or carbohydrate foods and that this potentiated reward is associated with response in areas critical for reward valuation, including the dorsal striatum and mediodorsal thalamus. We also show that individuals are better able to estimate the energy density of fat compared with carbohydrate and fat + carbohydrate foods, an effect associated with functional connectivity between visual (fusiform gyrus) and valuation (ventromedial prefrontal cortex) areas. These results provide the first demonstration that foods high in fat and carbohydrate are, calorie for calorie, valued more than foods containing only fat or carbohydrate and that this effect is associated with greater recruitment of central reward circuits.
进食后传递食物营养特性信息的信号对于调节进食行为至关重要。在这里，我们使用伴随 fMRI 扫描的拍卖任务证明，与同样熟悉、喜欢和热量相同的脂肪或碳水化合物食物相比，参与者更愿意为脂肪+碳水化合物支付更高的价格，并且这种增强的奖励与对奖励评估至关重要的区域的反应相关，包括背侧纹状体和中脑背侧丘脑。我们还表明，个体能够更好地估计脂肪的能量密度，而不是碳水化合物和脂肪+碳水化合物食物，这种效应与视觉（梭状回）和评估（腹内侧前额叶皮层）区域之间的功能连接有关。这些结果首次证明，与仅含脂肪或碳水化合物的食物相比，高热量和高碳水化合物的食物在卡路里方面的价值更高，并且这种效果与中枢奖励回路的更大募集有关。
