通过阴道给药孕酮拮抗剂预防妊娠：用于诱导月经和吸收的RU486棉塞

Pregnancy prevention by intravaginal delivery of a progesterone antagonist: RU486 tampon for menstrual induction and absorption.

作者信息

Hodgen G D

出版信息

Fertil Steril. 1985 Aug;44(2):263-7. doi: 10.1016/s0015-0282(16)48748-0.

Abstract

A progesterone antagonist (RU486) was administered to macaque monkeys by an intravaginal tampon for the achievement of both menstrual induction and absorption. The study was conducted in three parts: (1) postcoital treatment beginning 3 days after potential fertilization; (2) treatment on extended cycle days 34 to 37 after a "missed" menstrual flow after mating; and (3) luteal phase (cycle days 22 to 25) treatment in noncoital cycles. Our findings demonstrate pregnancy prevention and/or interruption when these treatments are employed.

摘要

通过阴道棉塞向猕猴施用孕酮拮抗剂（RU486），以实现月经诱导和吸收。该研究分三个部分进行：（1）在可能受精后3天开始进行性交后治疗；（2）在交配后“月经推迟”后的延长周期第34至37天进行治疗；（3）在非性交周期的黄体期（周期第22至25天）进行治疗。我们的研究结果表明，采用这些治疗方法可预防和/或中断妊娠。