多氯联苯及相关化合物在各类动物中的比较毒性。
Comparative toxicity of PCBs and related compounds in various species of animals.
作者信息
McConnell E E
出版信息
Environ Health Perspect. 1985 May;60:29-33. doi: 10.1289/ehp.856029.
Abstract
There are several basic principles that apply to the clinicopathologic syndrome produced by polychlorinated biphenyls (PCBs). They are as follows: The degree of halogenation and position of the halogen atoms determine the potency of PCB, PBB, CDD, CDF and CN; in a given species of animals, the clinicopathologic syndrome induced by PCB is comparable to that induced by polybrominated biphenyls (PBB), chlorinated dibenzo-p-dioxins (CDD), chlorinated dibenzofurans (CDF), and chlorinated naphthalenes (CN) when an equitoxic dose is achieved; The clinicopathologic syndrome is different in each species of animals; Different species of animals vary in their susceptibility to intoxication; intoxication is more readily effected in young animals that in adults; at lethal doses the time between exposure and death is prolonged (greater than 2 weeks).
摘要
有几条适用于多氯联苯（PCBs）所产生的临床病理综合征的基本原则。具体如下：卤化程度和卤原子的位置决定了多氯联苯、多溴联苯、二恶英、呋喃和氯化萘的毒性；在给定的动物物种中，当达到等毒性剂量时，多氯联苯诱发的临床病理综合征与多溴联苯（PBB）、二氯二苯并对二恶英（CDD）、二氯二苯并呋喃（CDF）和氯化萘（CN）诱发的临床病理综合征相当；临床病理综合征在每种动物物种中都有所不同；不同动物物种对中毒的易感性各不相同；幼龄动物比成年动物更容易发生中毒；在致死剂量下，接触与死亡之间的时间会延长（超过2周）。
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