The dynamic nature of DNA-strand breaks present in differentiating muscle cells and quiescent lymphocytes.
作者信息
Farzaneh F, Shall S, Johnstone A P
出版信息
FEBS Lett. 1985 Sep 9;189(1):62-6. doi: 10.1016/0014-5793(85)80842-5.
PMID:2993031
Abstract
Cellular differentiation in a number of eukaryotic systems is associated with changes in the number of DNA-strand breaks and involves the activity of adenosine diphosphoribosyl transferase (ADPRT). DNA-strand breaks are essential for activation of nuclear ADPRT, the activity of which is required for efficient religation of DNA-strand breaks. In this study we demonstrate the dynamic nature of DNA-strand breaks formed in the genome of differentiating avian skeletal muscle cells and quiescent human lymphocytes. Inhibition of ADPRT activity blocks DNA-strand ligation in both cell types and leads to the accumulation of a higher number of strand breaks.
摘要
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