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肺脂肪栓塞与冠状动脉淀粉样变性

Pulmonary Fat Embolism and Coronary Amyloidosis.

作者信息

Lever Veronica, Erdini Francesco, Ghimenton Claudio, Novelli Luca, Brunelli Matteo, Barbareschi Mattia, Mazzoleni Guido, Vermiglio Elisa, Mantovani Alessandro, Cima Luca, Valotto Giovanni, Eccher Albino

机构信息

Pathology Unit, Department of Diagnostics and Public Health, University and Hospital Trust of Verona, Verona, Italy.

Pathology Unit, Careggi University Hospital, Firenze, Italy.

出版信息

Am J Case Rep. 2018 Jun 25;19:744-747. doi: 10.12659/AJCR.908561.

Abstract

BACKGROUND Fat embolism syndrome is a well-known complication in orthopedic and trauma surgery, caused by a massive release of fat into the circulation that can lead to cardiopulmonary insufficiency and multiorgan failure. CASE REPORT We present the case of a 72-year-old man with osteoarthritis who underwent an elective right cementless total hip arthroplasty. Two hours after surgery, the patient lost consciousness and was found hypotensive and with reduced oxygen saturation, with a severe right heart dilatation at echocardiographic evaluation. Death occurred after cardiopulmonary resuscitation attempts. Post-mortem microscopic examination revealed that the final cause of death was pulmonary fat embolism associated with coronary amyloidosis and atherosclerosis. CONCLUSIONS This case called our attention on the sudden onset of fat embolism syndrome after arthroplasty and the insidious nature of amyloidosis infiltrative disease. The autopsy findings substantially aided understanding the immediate cause of death.

摘要

背景

脂肪栓塞综合征是骨科和创伤外科手术中一种广为人知的并发症,由大量脂肪进入血液循环引起,可导致心肺功能不全和多器官功能衰竭。病例报告:我们报告一例72岁患骨关节炎的男性患者,其接受了择期右侧非骨水泥型全髋关节置换术。术后两小时,患者失去意识,被发现血压降低、血氧饱和度下降,超声心动图评估显示右心严重扩张。在进行心肺复苏尝试后患者死亡。尸检显微镜检查显示,死亡的最终原因是与冠状动脉淀粉样变性和动脉粥样硬化相关的肺脂肪栓塞。结论:该病例引起了我们对关节置换术后脂肪栓塞综合征突然发作以及淀粉样变性浸润性疾病隐匿性的关注。尸检结果极大地有助于理解直接死因。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/7b7e/6047570/393d886f698f/amjcaserep-19-744-g001.jpg

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