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改进空间:女性机构间HIV研究中15年的HIV-糖尿病护理连续过程

Room for Improvement: The HIV-Diabetes Care Continuum Over 15 Years in the Women's Interagency HIV Study.

作者信息

Colasanti Jonathan, Galaviz Karla I, Christina Mehta C, Palar Kartika, Schneider Michael F, Tien Phyllis, Adimora Adaora A, Alcaide Maria, Cohen Mardge H, Gustafson Deborah, Karim Roksana, Merenstein Daniel, Sharma Anjali, Wingood Gina, Marconi Vincent C, Ofotokun Ighovwerha, Ali Mohammed K

机构信息

Division of Infectious Diseases, Department of Medicine, Emory University School of Medicine, Atlanta, Georgia.

Department of Global Health, Rollins School of Public Health, Emory University, Atlanta, Georgia.

出版信息

Open Forum Infect Dis. 2018 May 22;5(6):ofy121. doi: 10.1093/ofid/ofy121. eCollection 2018 Jun 1.

Abstract

BACKGROUND

Gains in life expectancy through optimal control of HIV infection with antiretroviral therapy (ART) may be threatened if other comorbidities, such as diabetes, are not optimally managed.

METHODS

We analyzed cross-sectional data of the Women's Interagency HIV Study (WIHS) from 2001, 2006, and 2015. We estimated the proportions of HIV-positive and HIV-negative women with diabetes who were engaged in care and achieved treatment goals (hemoglobin A1c [A1c] <7.0%, blood pressure [BP] <140/90 mmHg, low-density lipoprotein [LDL] cholesterol <100 mg/dL, not smoking) and viral suppression. Repeated-measures models were used to estimate the adjusted prevalence of achieving each diabetes treatment goal at each time point, by HIV status.

RESULTS

We included 486 HIV-positive and 258 HIV-negative women with diabetes. In 2001, 91.8% visited a health care provider, 60.7% achieved the A1c target, 70.5% achieved the BP target, 38.5% achieved the LDL cholesterol target, 49.2% were nonsmokers, 23.3% achieved combined ABC targets (A1c, BP, and cholesterol), and 10.9% met combined ABC targets and did not smoke. There were no differences by HIV status, and patterns were similar in 2006 and 2015. Among HIV-positive women, viral suppression increased from 41% in 2001 to 87% in 2015 compared with 8% and 13% achieving the ABC goals and not smoking. Viral suppression was not associated with achievement of diabetes care goals.

CONCLUSIONS

Successful management of HIV is outpacing that of diabetes. Future studies are needed to identify factors associated with gaps in the HIV-diabetes care continuum and design interventions to better integrate effective diabetes management into HIV care.

摘要

背景

如果糖尿病等其他合并症未得到最佳管理,那么通过抗逆转录病毒疗法(ART)对HIV感染进行最佳控制所带来的预期寿命增长可能会受到威胁。

方法

我们分析了2001年、2006年和2015年妇女机构间HIV研究(WIHS)的横断面数据。我们估计了患有糖尿病的HIV阳性和HIV阴性女性接受治疗并实现治疗目标(糖化血红蛋白[A1c]<7.0%、血压[BP]<140/90 mmHg、低密度脂蛋白[LDL]胆固醇<100 mg/dL、不吸烟)以及病毒抑制的比例。采用重复测量模型按HIV状态估计每个时间点实现每项糖尿病治疗目标的校正患病率。

结果

我们纳入了486名患有糖尿病的HIV阳性女性和258名HIV阴性女性。2001年,91.8%的患者就诊于医疗服务提供者,60.7%的患者实现了A1c目标,70.5%的患者实现了血压目标,38.5%的患者实现了LDL胆固醇目标,49.2%的患者不吸烟,23.3%的患者实现了ABC综合目标(A1c、血压和胆固醇),10.9%的患者达到ABC综合目标且不吸烟。按HIV状态无差异,2006年和2015年的模式相似。在HIV阳性女性中,病毒抑制率从2001年的41%增至2015年的87%,而实现ABC目标且不吸烟的比例分别为8%和13%。病毒抑制与糖尿病治疗目标的实现无关。

结论

HIV的成功管理超过了糖尿病。未来需要开展研究以确定与HIV-糖尿病护理连续过程中的差距相关的因素,并设计干预措施,以便更好地将有效的糖尿病管理纳入HIV护理中。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9136/6007350/cc4407403c2f/ofy12101.jpg

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