Burgess A W
Aust N Z J Surg. 1985 Apr;55(2):105-10. doi: 10.1111/j.1445-2197.1985.tb00868.x.
Recent advances in protein chemistry and genetic engineering have revealed new information about the molecular lesions involved in the induction and maintenance of cancer cells. It is now known that a single base change in the DNA of human cells leads to cancer. The normal pathway of proliferation and differentiation is perturbed by changes to molecules involved in the intracellular biochemical pathways controlled by growth factors. Some cancer cells appear to produce their own growth factor, others have higher concentrations of growth factor receptors on their surface and others have mutated versions of the intracellular proteins linked to the growth factor receptors. This increased understanding of growth control in normal and neoplastic cell populations is gradually providing a foundation for new approaches to cancer therapy.
蛋白质化学和基因工程的最新进展揭示了有关癌细胞诱导和维持过程中分子损伤的新信息。现在已知人类细胞DNA中的单个碱基变化会导致癌症。正常的增殖和分化途径会受到生长因子所控制的细胞内生化途径中相关分子变化的干扰。一些癌细胞似乎会产生自身的生长因子，另一些癌细胞表面具有更高浓度的生长因子受体，还有一些癌细胞具有与生长因子受体相关的细胞内蛋白质的突变形式。对正常和肿瘤细胞群体生长控制的这种深入理解正逐渐为癌症治疗的新方法奠定基础。
