Ghasemi P, Sahraee T, Mohammadi A
Department of Electrical and Computer Engineering, Shahid Beheshti University, Tehran, Iran.
Department of Electronic Engineering, Tabriz University, Tabriz, Iran.
J Biomed Phys Eng. 2018 Jun 1;8(2):209-216. eCollection 2018 Jun.
Deep brain stimulation (DBS) is known as the most effective technique in the treatment of neurodegenerative diseases, especially Parkinson disease (PD) and epilepsy. Relative healing and effective control of disease symptoms are the most significant reasons for the tangible tendency in use and development of this technology. Nevertheless, more cellular and molecular investigations are required to reveal the detailed mechanism of DBS. Here, we reviewed the methods, challenges and the ways to overcome the limitations of DBS. Also, challenges in probe fabrication technology, material selection, related mechanical stability and biocompatibility concerns are discussed. Finally, closed- and open-loop stimulation systems were compared.
深部脑刺激（DBS）是治疗神经退行性疾病，尤其是帕金森病（PD）和癫痫最有效的技术。相对治愈和有效控制疾病症状是该技术在使用和发展中明显倾向的最重要原因。然而，需要更多的细胞和分子研究来揭示DBS的详细机制。在这里，我们回顾了DBS的方法、挑战以及克服其局限性的方法。此外，还讨论了探针制造技术、材料选择、相关机械稳定性和生物相容性方面的挑战。最后，比较了闭环和开环刺激系统。
