可乐唑啉，豚鼠回肠中的一种α2肾上腺素能受体拮抗剂。
Cirazoline, an alpha 2-adrenoceptor antagonist in guinea-pig ileum.
作者信息
Mottram D R, Saggar P
出版信息
Gen Pharmacol. 1985;16(4):367-70. doi: 10.1016/0306-3623(85)90197-1.
PMID:2995194
Abstract
Prejunctional effects of cirazoline have been investigated in guinea pig ileum. At high concentrations cirazoline has been shown to have antimuscarinic activity, pA2 5.25 +/- 0.29. At concentrations below those producing blockade of acetylcholine, cirazoline blocks the prejunctional alpha 2-adrenoceptor activity of clonidine, pA2 6.81 +/- 0.22, and alpha-methylnoradrenaline. Results are discussed in the light of controversial evidence for the activity of cirazoline on alpha-adrenoceptors.
摘要
已在豚鼠回肠中研究了西拉唑啉的节前效应。在高浓度下，西拉唑啉已被证明具有抗毒蕈碱活性，pA2为5.25±0.29。在低于产生乙酰胆碱阻断作用的浓度下，西拉唑啉可阻断可乐定的节前α2-肾上腺素能受体活性，pA2为6.81±0.22，以及α-甲基去甲肾上腺素的活性。根据关于西拉唑啉对α-肾上腺素能受体活性的有争议证据对结果进行了讨论。
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