精神分裂症患者社会情感评估时双侧前额叶 rTMS 对大脑激活的影响：一项双盲、随机、探索性研究。
Effects of bilateral prefrontal rTMS on brain activation during social-emotional evaluation in schizophrenia: A double-blind, randomized, exploratory study.
机构信息
Department of Neuroscience and BCN Neuroimaging Center, University of Groningen, University Medical Center Groningen, Postbox 30.001, Internal Code FA32, 9700 RB Groningen, Netherlands; Department of Psychiatry & Rob Giel Research Center, University of Groningen, University Medical Center Groningen, Postbox 30.001, Internal Code CC72, 9700 RB Groningen, Netherlands.
Department of Neuroscience and BCN Neuroimaging Center, University of Groningen, University Medical Center Groningen, Postbox 30.001, Internal Code FA32, 9700 RB Groningen, Netherlands; Lentis Research, Lentis Psychiatric Institute, Hereweg 80, 9725 AG Groningen, Netherlands.
出版信息
Schizophr Res. 2018 Dec;202:210-211. doi: 10.1016/j.schres.2018.06.051. Epub 2018 Jun 27.
This exploratory study reports on the effects of Repetitive Transcranial Magnetic Stimulation (rTMS) on (prefrontal) brain activity changes during ambiguous emotional evaluation in patients with schizophrenia. Before and after randomly assigned treatment with active and sham rTMS, patients performed the Wall of Faces task during fMRI scanning. fMRI analysis showed that rTMS treatment resulted in reduced activation of striato-fronto-parietal brain areas, while activation increased compared to baseline after sham. Thus, prefrontal rTMS may normalize an increased brain response to ambiguous emotional stimuli, but future studies should confirm these findings.
本探索性研究报告了重复经颅磁刺激（rTMS）对精神分裂症患者在进行模糊情绪评估时（前额叶）大脑活动变化的影响。在随机接受真 rTMS 和假 rTMS 治疗前后，患者在 fMRI 扫描期间执行面部墙任务。fMRI 分析表明，rTMS 治疗导致纹状体-额-顶-颞叶大脑区域的激活减少，而与假刺激相比，治疗后激活增加。因此，前额叶 rTMS 可能使对模糊情绪刺激的大脑反应正常化，但未来的研究应证实这些发现。
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