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[与纳武单抗治疗相关的双侧葡萄膜炎]

[Bilateral uveitis associated with nivolumab therapy].

作者信息

Rémond A-L, Barreau E, Le Hoang P, Bodaghi B

机构信息

Hôpital Pitié-Salpêtrière, 47-83, boulevard de l'hôpital, 75013 Paris, France.

Kremlin-Bicêtre, 31, rue du Général Leclerc, 94270 Kremlin-Bicêtre, France.

出版信息

J Fr Ophtalmol. 2018 Jun;41(6):536-539. doi: 10.1016/j.jfo.2017.10.009. Epub 2018 Jun 27.

Abstract

Immune-related adverse events (IRAEs) are rare but serious adverse events that may be associated with inhibitors of few immune control points. The purpose here is to report the case of an inflammatory ocular disease, potentially linked to the immunity and use of nivolumab, a new immunological agent used for the treatment of a solid tumor. In spite of the involvement of this treatment in the onset of inflammation, we must always seek another cause. It is possible to continue this treatment by considering the benefit/risk balance for each patient. Close collaboration between oncologists and ophthalmologists is necessary in the diagnosis and rapid management of these IRAE ocular related to these new emerging therapies.

摘要

免疫相关不良事件(IRAEs)虽罕见但严重,可能与少数免疫检查点抑制剂有关。本文旨在报告一例炎性眼病病例,其可能与免疫及用于治疗实体瘤的新型免疫药物纳武单抗的使用有关。尽管这种治疗参与了炎症的发生,但我们仍必须始终寻找其他原因。通过考虑每位患者的获益/风险平衡,可以继续这种治疗。肿瘤学家和眼科医生之间的密切合作对于这些与新兴疗法相关的IRAEs眼部病变的诊断和快速处理是必要的。

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