住院会增加痛风患者急性关节炎发作的风险：一项长达 20 年的基于人群的研究。
Hospitalization Increases the Risk of Acute Arthritic Flares in Gout: A Population-based Study over 2 Decades.
机构信息
From the Division of Rheumatology, Mayo Clinic College of Medicine and Science, Rochester, Minnesota, USA.
N. Zleik, MD, Rheumatology Fellow, Division of Rheumatology, Augusta University; M.M. Elfishawi, MD, Internal Medicine Resident, Icahn School of Medicine at Mount Sinai; Z. Kvrgic, CCRP, Study Coordinator, Mayo Clinic; C.J. Michet Jr., MD, Consultant, Mayo Clinic; C.S. Crowson, MS, Associate Professor, Mayo Clinic; E.L. Matteson, MD, MPH, Consultant, Mayo Clinic; T. Bongartz, MD, MS, Vanderbilt University.
出版信息
J Rheumatol. 2018 Aug;45(8):1188-1191. doi: 10.3899/jrheum.171320. Epub 2018 Jul 1.
OBJECTIVE
To assess in-hospital gout flares in patients with gout.
METHODS
Hospitalizations were evaluated for gout flares in a cohort of Olmsted County, Minnesota, residents with incident gout in 1989-1992 or 2009-2010.
RESULTS
There were 429 patients followed up to 5 years. Of these, 169 patients experienced 454 hospitalizations. Hospitalization rates increased without reaching statistical significance from 1989-1992 to 2009-2010 [rate ratio (RR) 1.19, 95% CI 0.98-1.45]. The gout flare rate increased significantly during hospitalization (RR 10.2, 95% CI 6.8-14.5). In-hospital gout flare increased the average hospital stay by 1.8 days (p < 0.001).
CONCLUSION
Hospitalization increased the risk of gout flares 10-fold. In-hospital gout flares were associated with longer hospitalization.
目的
评估痛风患者住院期间的痛风发作情况。
方法
在明尼苏达州奥姆斯特德县的一个队列中，评估了 1989-1992 年或 2009-2010 年期间患有痛风的居民中痛风发作的住院情况。
结果
共有 429 名患者随访 5 年。其中，169 名患者经历了 454 次住院。住院率从 1989-1992 年到 2009-2010 年有所增加，但没有达到统计学意义[发生率比（RR）为 1.19，95%可信区间（CI）为 0.98-1.45]。住院期间痛风发作率显著增加（RR 10.2，95%CI 6.8-14.5）。院内痛风发作使平均住院时间延长了 1.8 天（p<0.001）。
结论
住院会使痛风发作的风险增加 10 倍。院内痛风发作与住院时间延长有关。
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