一例脑脊液人绒毛膜促性腺激素浓度升高的颅咽管瘤被误诊为生殖细胞瘤。
A Craniopharyngioma Associated With Elevated Cerebrospinal Fluid HCG Concentrations Misdiagnosed as a Germinoma.
作者信息
Gu Weijun, Gu Weizhong, Gu Yulin, Li Jie, Yang Guoqing, Guo Qinghua, Zang Li, Du Jin, Pei Yu, Ba Jianming, Lv Zhaohui, Dou Jingtao, Mu Yiming
机构信息
Department of Endocrinology, Chinese People's Liberation Army General Hospital, Beijing, China.
Department of Neurology, The Second People's Hospital of Datong, Shanxi, China.
出版信息
Front Neurol. 2018 Jun 14;9:449. doi: 10.3389/fneur.2018.00449. eCollection 2018.
Craniopharyngiomas and germinomas are both rare cranial tumors that most commonly present during childhood or adolescence. Although these tumors have different origins, their clinical and radiological features may be similar. In this article, we report the case of a 35-year female patient with clinical and radiological findings and increased human chorionic gonadotrophin (HCG) levels in the cerebrospinal fluid (CSF) that were consistent with a germinoma. However, pathological analysis revealed a craniopharyngioma. This case report indicates that HCG, which is regarded as a specific tumor marker for germinomas in the differential diagnosis of intracranial lesions, is also detectable in other kinds of suprasellar tumors, such as craniopharyngiomas.
颅咽管瘤和生殖细胞瘤均为罕见的颅内肿瘤，最常见于儿童期或青春期。尽管这些肿瘤起源不同，但其临床和影像学特征可能相似。在本文中，我们报告了一例35岁女性患者，其临床和影像学表现以及脑脊液（CSF）中人类绒毛膜促性腺激素（HCG）水平升高，这些表现与生殖细胞瘤相符。然而，病理分析显示为颅咽管瘤。本病例报告表明，在颅内病变的鉴别诊断中被视为生殖细胞瘤特异性肿瘤标志物的HCG，在其他类型的鞍上肿瘤（如颅咽管瘤）中也可检测到。
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